| dc.description.abstract | Objectives: This experimental study used a rat model to investigate the effect of Matricaria chamomilla (MC) extract on histological damage and oxidative stress induced by torsion/detorsion in adult rat ovary. Materials and Methods: In our experimental study, 28 female Wistar rats were used. They were randomly divided into 4 groups; G1, Sham group; G2, Ovarian torsion for 3 hours followed by detorsion 10 days (TDO); G3, Ovarian torsion for 3 hours and then received 200 mg/kg hydroalcoholic extracts of MC, 30 minutes before detorsion, followed by detorsion (10 days) (TDOMC); G4, received 200 mg/kg of hydroalcoholic extracts of MC. After the 10-day reperfusion period, blood sampling was done and blood levels of estrogen, testosterone, some oxidative stress markers and anti-oxidant enzymes were assayed. Further assessment was carried out by histomorphometry on 10-day postprocedure. Results: Comparison of the histological parameters showed a significant change in the G2 group as compared with other groups. The levels of estrogen, glutathione peroxidase (GPx), and superoxide dismutase (SOD) significantly decreased in G2 group, and increased in G3 and G4 groups, and the malondialdehyde level increased in the duration of ischemia. Treatment by MC decreased the malondialdehyde level in G3 and G4 groups. Conclusion: The results of this study showed that MC could reduce oxidative stress and tissue damages following ovarian torsion/detorsion. | |
