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Solubility of sildenafil citrate in polyethylene glycol 400+water mixtures at various temperatures

dc.contributor.authorPirhayati, FH
dc.contributor.authorShayanfar, A
dc.contributor.authorRahimpour, E
dc.contributor.authorBarzegar-Jalali, M
dc.contributor.authorMartinez, F
dc.contributor.authorJouyban, A
dc.date.accessioned2018-08-26T07:18:54Z
dc.date.available2018-08-26T07:18:54Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/45431
dc.description.abstractThe solubility of sildenafil citrate (SC) in binary aqueous mixtures of polyethylene glycol 400 (PEG 400) were determined at 293.2, 298.2, 303.2, 3082 and 3132 K. Density of the SC saturated solutions over the entire solvent composition and temperature range was measured by a pycnometer. The solubility and densities data were correlated by two models, which are the van't Hoff and Jouyban-Acree model. The apparent thermodynamic properties, dissolution enthalpy, dissolution entropy, and Gibbs free energy change of dissolution process of SC in all the mixed solvents were calculated according to van't Hoff and Gibbs equations. (C) 2017 Elsevier B.V. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofJOURNAL OF MOLECULAR LIQUIDS
dc.subjectSolubility
dc.subjectDensity
dc.subjectSildenafil citrate
dc.subjectBinary solvent mixture
dc.subjectJouyban-Acree model
dc.subjectVan't Hoff equation
dc.titleSolubility of sildenafil citrate in polyethylene glycol 400+water mixtures at various temperatures
dc.typeArticle
dc.citation.volume240
dc.citation.spage268
dc.citation.epage272
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1016/j.molliq.2017.05.057


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