Show simple item record

dc.contributor.authorMahmoodzadeh, F
dc.contributor.authorAbbasian, M
dc.contributor.authorJaymand, M
dc.contributor.authorAmirshaghaghi, A
dc.date.accessioned2018-08-26T07:14:36Z
dc.date.available2018-08-26T07:14:36Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/45177
dc.description.abstractA novel thermo- and pH-responsive thiol-end-capped ABC triblock copolymer, namely poly(acrylic acid)-block-poly(N-isopropylacrylamide)-block-poly(epsilon-caprolactone)-SH (PAA-b-PNIPAAm-b-PCL-SH), was synthesized using a combination of ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization techniques. The chemical structures of all samples were characterized by means of Fourier transform infrared and H-1 NMR spectroscopies. The molecular weight of each segment was investigated using both H-1 NMR spectroscopy and gel permeation chromatography. The self-assembly behavior of the PAA-b-PNIPAAm-b-PCL-SH triblock copolymer under thermal and pH stimuli was fully investigated by means of fluorescence and UV-visible spectroscopies as well as dynamic light scattering measurements. The critical micelle concentration for the synthesized triblock copolymer was determined to be 0.0178 g L-1 using the fluorescence probe technique. The average size of PAA-b-PNIPAAm-b-PCL-SH micelles was determined to be 25 nm using transmission electron microscopy observations, and its lower critical solution temperature was determined to be 41-43 degrees C using UV-visible spectroscopy. (c) 2017 Society of Chemical Industry
dc.language.isoEnglish
dc.relation.ispartofPOLYMER INTERNATIONAL
dc.subjecttriblock copolymer
dc.subjectRAFT polymerization
dc.subjectself-assembly
dc.subjectstimuli-responsive
dc.subjectde novo drug delivery
dc.titleA novel dual stimuli-responsive thiol-end-capped ABC triblock copolymer: synthesis via reversible addition-fragmentation chain transfer technique, and investigation of its self-assembly behavior
dc.typeArticle
dc.citation.volume66
dc.citation.issue11
dc.citation.spage1651
dc.citation.epage1661
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1002/pi.5428


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record