Synthesis of azo dyes possessing N-heterocycles and evaluation of their anticancer and antibacterial properties

Abstract

A series of 4-(1-azolyl)aniline derivatives (azole = imidazole, benzimidazole, pyrazole, 3-methylpyrazole, and 4-methylpyrazole) underwent diazotization reaction by NaNO2/HCl. The diazonium salts were consequently treated with aromatics such as phenol, N,N-dimethylaniline, 2-naphthol, and 8-hydroxyquinoline to give the coupled azo compounds. The antibacterial activities of some of the products were evaluated against Gram-negative [Escherichia coli (ATCC 25922)] and Gram-positive [Staphylococcus aureus (ATCC 25923)] bacteria. Moreover, in vitro examinations for a series of the products corroborated anticancer activities against MCF7 breast cancer cells. [GRAPHICS]