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dc.contributor.authorAmini, S
dc.contributor.authorAbak, A
dc.contributor.authorEstiar, MA
dc.contributor.authorMontazeri, V
dc.contributor.authorAbhari, A
dc.contributor.authorSakhinia, E
dc.date.accessioned2018-08-26T07:12:34Z
dc.date.available2018-08-26T07:12:34Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/44743
dc.description.abstractBackground: miR-221 and miR-222 are homologous miRNAs located in tandem, within 1 kb from each other, on human x chromosome. Recent studies declared that microRNA-222 is aberrantly expressed in various malignancies. The goal of this research was to measure the expression level of has-miR-222-3P and reveal its diagnostic and prognostic importance in breast malignancy. Methods: In this study, 40 pairs of cancerous and matched adjacent non-cancerous breast tissue were collected from patients, and real-time PCR was used to measure the relative expression of miR-222. Results: Our study clarified that microRNA-222 is enhanced in tumor tissues in comparison with normal tissue margins (p <= 0.05) and overexpression of miR-222 was not associated with clinicopathological factors such as age, BMI, menopausal status, histological type, grade, stage, tumor size, lymph node metastasis (p > 0.05). The receiver operating characteristic (ROC) curve analysis displayed an optimum cutoff point of < 4.17 to prove that miR-222 is a useful biomarker in breast cancer diagnosis. Conclusions: Our findings on miR-222 suggest that it could be a potentially useful target for control and management of breast malignancy.
dc.language.isoEnglish
dc.relation.ispartofCLINICAL LABORATORY
dc.subjectbreast cancer
dc.subjectmicroRNA-222
dc.subjectreal-time PCR
dc.subjectbiomarker
dc.subjectgene expression
dc.titleExpression Analysis of MicroRNA-222 in Breast Cancer
dc.typeArticle
dc.citation.volume64
dc.citation.issue4
dc.citation.spage491
dc.citation.epage496
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.7754/Clin.Lab.2017.171002


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