Solubility of celecoxib in {2-propanol (1) + water (2)} mixtures at various temperatures: Experimental data and thermodynamic analysis

Abstract

The objective of the present investigation is to study the effect of a cosolvent (2-propanol) on the solubility of celecoxib at different temperatures. The measured solubility data using the shake-flask method was correlated/predicted by cosolvency and thermodynamic models. The solubility of celecoxib is increased with the addition of 2-propanol to the aqueous solutions and increased temperature leads to enhance the solubility of celecoxib in a given solvent composition and reaches a maximum value in neat 2-propanol. The results show that 2-propanol is an adequate solubilizing agent for celecoxib. The developed cosolvency and thermodynamic models i.e. Jouyban-Acree and van't Hoff models are capable to predict the solubility of celecoxib in different fractions of (2-propanol + water) solvent mixtures at various temperatures. Furthermore, apparent thermodynamic quantities of the dissolution processes were calculated by using the Gibbs and van't Hoff equations, as well as the preferential solvation of the drug, which was calculated based on the Inverse Kirkwood-Buff integrals method. (C) 2018 Elsevier B.V. All rights reserved.