Analysis of the effect of resveratrol and quercetin separately and together on Wnt Signaling path regulators, tumor differentiation, dietary intake and weight changes in rat's empirical colon cancer

Abstract

Cancer is one of the most common diseases in the world. 1 out of 8 deaths in the world happen as a result of cancer. Cancer is the third cause of mortality in Iran. Colon cancer is the fourth cause of mortality at the world and annually 1.2 million people with the disease are being diagnosed. About 8% of overall mortality rate is associated with colon cancer. Colon cancer has considerably increased in Iran over the last 3 decades and it is the second most common cancer in Iran according to the annual report of National Cancer Institute of Iran. Spread of colon cancer in Iran can be estimated to be 8 out of 100,000 people. 3,641 new cases of cancer are reported annually in Iran and 2,262 people die in Iran every year as a result of colon cancer. Spread of the disease in the Iranian population is equal to 22% and accordingly and because of conflicting reports on effectiveness of resveratrol and quercetin in different steps of cancer, and lack of existence of study on simultaneous effect of the two compounds on colon cancer in vivo, this study intends to evaluate their effect together, so that positive results obtained from this study can be generalized to human studies.