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dc.contributor.authorHassanpour, M
dc.contributor.authorCheraghi, O
dc.contributor.authorBrazvan, B
dc.contributor.authorHiradfar, A
dc.contributor.authorAghamohammadzadeh, N
dc.contributor.authorRahbarghazi, R
dc.contributor.authorNouri, M
dc.date.accessioned2018-08-26T06:35:42Z
dc.date.available2018-08-26T06:35:42Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/44248
dc.description.abstractBy virtue of lifestyle change, incidence of diabetes mellitus type 2 is increasingly being raised with different up-surging pathologies. It was showed that endothelial progenitor cells (EPCs) were disqualified in neo-angiogenesis induction. Besides, to an aborted differentiation property, malfunctioned paracrine activities worsen off vascular abnormality. Nano-scaled exosomes play essential roles in reciprocal cell-cell crosstalk via bioactive molecules. To address the effect of diabetic serum on exosome secretion capacity, EPCs were exposed to diabetic condition for seven days. In addition to in-vitro tubulogenesis, migration and LDL uptake assessment, exosome release capacity, and expression profiles of three genes participating in exosome kinetics, including CD63, Alix and Rab27a. revealed by Real-time PCR method. Data showed diabetic sera not only abolished the in-vitro tubulogenesis. migration and LDL uptake properties but also decreased exosome release and expression of related genes. This study sheds lights on the adverse effect of diabetic condition on exosome kinetics in EPCs.
dc.language.isoEnglish
dc.relation.ispartofIRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
dc.subjectEndothelial progenitor cells
dc.subjectDiabetes
dc.subjectExosome
dc.subjectKinetics
dc.titleChronic Exposure of Human Endothelial Progenitor Cells to Diabetic Condition Abolished the Regulated Kinetics Activity of Exosomes
dc.typeArticle
dc.citation.volume17
dc.citation.issue3
dc.citation.spage1068
dc.citation.epage1080
dc.citation.indexWeb of science


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