نمایش پرونده ساده آیتم

dc.contributor.authorAliakbarinodehi, N
dc.contributor.authorStradolini, F
dc.contributor.authorNakhjavani, SA
dc.contributor.authorTzouvadaki, I
dc.contributor.authorTaurino, I
dc.contributor.authorDe Micheli, G
dc.contributor.authorCarrara, S
dc.date.accessioned2018-08-26T06:35:35Z
dc.date.available2018-08-26T06:35:35Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/44227
dc.description.abstractNano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the electro-active surface area (EASA). In this paper, an analytical calculation of the deposited EASA is presented and experimentally validated by comparing two kinds of nano-structured electrochemical sensors modified with multi-walled carbon nanotubes (MWCNTs) and fullerenes. Further, the two differently nano-structured electrodes, prepared with equal optimum EASA, have been adopted as novel approach in the detection of paracetamol (APAP) and midazolam (MZ), two largely adopted and complementary sedative drugs. We have used the novel approach to let emerge the different nano-scale structures' sensing performance at the same equivalent EASA. The analytical method for EASA calculation has been recently validated by our group on different nano-materials; hence the aim of the actual work is to present, for the first time, its efficient applicability also in comparing the performance of different allotropes of the same nature (carbon-based) in drug sensing, e.g., MZ and APAP. This paper also includes the comparison in undiluted human serum (HS), proposed here as complex bio-sample, to confirm the validity of our novel approach close to real applications. With respect to fullerenes, the MWCNTs-modified electrodes obtained the best limit of detection values in HS detection, as 0.3518 mu M and 0.5367 mm for APAP and MZ, respectively. Scanning electron microscopy analysis also confirmed the higher quality of MWCNTs-based surface in terms of homogeneity and denser coverage of the surface with respect to fullerene-based one, with a better-packed aggregate of assembled structures.
dc.language.isoEnglish
dc.relation.ispartofIEEE SENSORS JOURNAL
dc.subjectAnesthetics
dc.subjectelectrochemistry
dc.subjectEASA
dc.subjecthuman serum
dc.subjectnano-structured electrodes
dc.titlePerformance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum
dc.typeArticle
dc.citation.volume18
dc.citation.issue12
dc.citation.spage5073
dc.citation.epage5081
dc.citation.indexWeb of science
dc.identifier.DOIhttps://doi.org/10.1109/JSEN.2018.2828416


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