| dc.contributor.author | Jouyban, A | |
| dc.contributor.author | Fakhree, MA | |
| dc.contributor.author | Ghafourian, T | |
| dc.contributor.author | Saei, AA | |
| dc.contributor.author | Acree, WE | |
| dc.date.accessioned | 2018-08-26T06:33:21Z | |
| dc.date.available | 2018-08-26T06:33:21Z | |
| dc.date.issued | 2008 | |
| dc.identifier.uri | http://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/43688 | |
| dc.description.abstract | Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being approximately 13%. | |
| dc.language.iso | English | |
| dc.relation.ispartof | Die Pharmazie | |
| dc.subject | Algorithms | |
| dc.subject | Chemistry, Pharmaceutical | |
| dc.subject | Computer Simulation | |
| dc.subject | Data Interpretation, Statistical | |
| dc.subject | Ethanol | |
| dc.subject | Models, Chemical | |
| dc.subject | Models, Statistical | |
| dc.subject | Pharmaceutical Preparations | |
| dc.subject | Polyethylene Glycols | |
| dc.subject | Software | |
| dc.subject | Solubility | |
| dc.subject | Solvents | |
| dc.subject | Water | |
| dc.title | Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure. | |
| dc.type | article | |
| dc.citation.volume | 63 | |
| dc.citation.issue | 2 | |
| dc.citation.spage | 113 | |
| dc.citation.epage | 21 | |
| dc.citation.index | Pubmed | |
