Myeloperoxidase index and subtypes of acute myeloid leukemia.

Abstract

Acute myeloid leukemia (AML) should be classified into subtypes according to the French-American-British (FAB) or, preferably, the newer World Health Organization (WHO) classification schemes. FAB is purely a morphological classification. It does not determine treatment (except M3) or prognosis for the patient which requires cytogenetics. Haematological analyzer had been used for classification of leukaemia in several studies. Neutrophil myeloperoxidase activity (MPXI) can be performed by Technicon H1 (Bayer) automated cell counter. The aim of this study was the statement of myeloperoxidase index and subgroups of AML. In the study of medical records of 72 patients with AML from 2006-7, we found that MPXI was negative in M4 and M5 while 75% of M3 cases had high MPXI values. MPXI level may help to differentiate subtypes of AML.