Show simple item record

dc.contributor.authorHallaj-Nezhadi, S
dc.contributor.authorLotfipour, F
dc.contributor.authorDass, C
dc.date.accessioned2018-08-26T06:17:01Z
dc.date.available2018-08-26T06:17:01Z
dc.date.issued2010
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/43243
dc.description.abstractInterleukin-12 (Il-12) is a heterodimeric cytokine which has been proven to possess antitumor effects in various animal models via stimulating the immune system. However, the main problem associated with Il-12 protein delivery is its instability as well as cytotoxicity subsequent to systemic administration in rodents and in clinical trials. However, gene delivery can be used to deliver genes of interest to the tumor site. Hence, a large number of studies have been undertaken to deliver genes of interest to the tumor site through viral or non-viral vectors. Viral DNA delivery systems suffer from safety concern due to the toxicity of the viruses and strong immune response, while non-viral gene delivery systems proffer lower transfection efficiency. In contrast, nanometer-sized complexes of therapeutic DNA may prove to be more efficient for administration of therapeutic genes to solid tumors compared to administration of naked plasmid DNA. Nanoparticle-based gene delivery systems might be more pertinent, due to enhanced tissue penetrability, and improved cellular uptake. Il-12 gene delivery has already been reported with different nanoparticles containing DNA. This article provides a review on the in vivo and in vitro studies using various nanoparticles, for delivery of the Il-12 gene to neoplastic cells. The future of these promising approaches lies in the development of better techniques for preparing Il-12 gene delivery systems with complete efficiency of viral vectors in addition to the highest safety for cancer patients.
dc.language.isoEnglish
dc.relation.ispartofJournal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
dc.subjectAnimals
dc.subjectDNA
dc.subjectFemale
dc.subjectGene Transfer Techniques
dc.subjectGenetic Therapy
dc.subjectGenetic Vectors
dc.subjectHumans
dc.subjectInterleukin-12
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectNanoparticles
dc.subjectNeoplasms
dc.subjectPlasmids
dc.subjectTransfection
dc.subjectVaccines, DNA
dc.subjectViruses
dc.titleNanoparticle-mediated interleukin-12 cancer gene therapy.
dc.typearticle
dc.citation.volume13
dc.citation.issue3
dc.citation.spage472
dc.citation.epage85
dc.citation.indexPubmed


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record