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dc.contributor.authorBaharivand, N
dc.contributor.authorMahdavifard, A
dc.contributor.authorFouladi, RF
dc.date.accessioned2018-08-26T06:10:09Z
dc.date.available2018-08-26T06:10:09Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/42553
dc.description.abstractBoth oral and intraocular routes have been recommended for medication administration in toxoplasmic retinochoroiditis; however, available data, in support or against, are scarce. The objective of this study was to compare the efficacy of intravitreal clindamycin plus dexamethasone (IVCD) and conventional oral therapy (COT) including pyrimethamine, sulfadiazine, folinic acid and prednisone in active toxoplasmic retinochoroiditis. In this prospective randomized single-blind clinical trial, patients with active toxoplasmic retinochoroiditis received either IVCD (nآ =آ 32), or COT (nآ =آ 34) for 6آ weeks. Changes of best-corrected visual acuity, retinal lesion size, and vitreous inflammation before and after treatment, as well as complications/side-effects and recurrence rate within at least 2آ years of follow-up were compared between groups. Although all the variables improved significantly at 6آ weeks within each group, changes were comparable between the IVCD and COT receivers. There was only one case with hepatotoxicity in the COT group which responded favorably to drug change. No injection-related complication was observed. Recurrence rates were 12.5 and 14.7آ % in the IVCD and COT groups, respectively (pآ =آ 0.54). In conclusion, both IVCD and COT are equally effective against active toxoplasmic retinochoroiditis but the former is apparently safer and more convenient.
dc.language.isoEnglish
dc.relation.ispartofInternational ophthalmology
dc.subjectAdministration, Oral
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectChorioretinitis
dc.subjectClindamycin
dc.subjectDexamethasone
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectGlucocorticoids
dc.subjectHumans
dc.subjectIntravitreal Injections
dc.subjectMale
dc.subjectProspective Studies
dc.subjectSingle-Blind Method
dc.subjectToxoplasma
dc.subjectToxoplasmosis, Ocular
dc.subjectTreatment Outcome
dc.subjectYoung Adult
dc.titleIntravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial.
dc.typearticle
dc.citation.volume33
dc.citation.issue1
dc.citation.spage39
dc.citation.epage46
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1007/s10792-012-9634-1


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