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dc.contributor.authorNaghipour, B
dc.contributor.authorAghamohamadi, D
dc.contributor.authorAzarfarin, R
dc.contributor.authorMirinazhad, M
dc.contributor.authorBilehjani, E
dc.contributor.authorAbbasali, D
dc.contributor.authorGolzari, SE
dc.date.accessioned2018-08-26T06:08:11Z
dc.date.available2018-08-26T06:08:11Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/42282
dc.description.abstractDifferent additives have been used to prolong regional blockade. We designed a prospective, randomized, double-blind, controlled clinical trial to evaluate the effect of dexamethasone added to bupivacaine-fentanyl on the duration of postoperative analgesia via epidural catheterization.Seventy two adult patients scheduled for elective abdominal or thoracic surgery under epidural anesthesia were randomly allocated into two groups to receive either bupivacaine (0.5%) - fentanyl (50 microg) and dexamethasone (8 mg) in lumbar or thoracic epidural anesthesia (Dexa group, n=36), or bupivacaine-fentanyl and saline normal (control group, n=36) via epidural catheter. Duration of analgesia, postoperative pain score and IV analgesic use at first 24 hours were recorded and compared.Two patients were excluded (one in each group) due to unsuccessful blockade. Age, gender and duration of surgery were similar in the two groups (p>0.05). The duration of analgesia (372< or = 58.1 vs. 234.6+/- 24.3 min) was significantly longer and pain score and pentazocine use were less in the Dexa than the control group (37.1+/- 19.7 mg v.s. 73.1 +/- 17.6 mg, respectively; p=0.001).This study revealed that dexamethasone added to bupivacaine-fentanyl solution in epidural analgesia prolongs the duration of analgesia in abdominal or thoracic surgery.
dc.language.isoEnglish
dc.relation.ispartofMiddle East journal of anaesthesiology
dc.subjectAdult
dc.subjectAged
dc.subjectAnalgesia, Epidural
dc.subjectAnesthetics, Local
dc.subjectBupivacaine
dc.subjectDexamethasone
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPain, Postoperative
dc.subjectProspective Studies
dc.subjectTime Factors
dc.titleDexamethasone added to bupivacaine prolongs duration of epidural analgesia.
dc.typearticle
dc.citation.volume22
dc.citation.issue1
dc.citation.spage53
dc.citation.epage7
dc.citation.indexPubmed


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