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dc.contributor.authorBarar, J
dc.contributor.authorOmidi, Y
dc.date.accessioned2018-08-26T06:07:19Z
dc.date.available2018-08-26T06:07:19Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/42155
dc.description.abstractNon-viral lipid/polymeric vectors have widely been used as nanocarriers (NCs) for gene delivery. They possess large surface area to volume ratio and are able to interact with biomolecules through functional moieties, resulting in inadvertent biological impacts, in particular at genomic level. Thus, their genomic bio-signature needs to be investigated prior to use in vivo. Using high-throughput microarray and qPCR gene expression profiling techniques, we have reported the genomic impacts of lipid/polymeric NCs. Given the fact that the ultimate objectives of gene therapy may inevitably be impaired by nonspecific intrinsic genomic impacts of these NCs, here, we highlight their nonspecific genomic bio-signature. We envision that better understanding on the genotoxicity of gene delivery NCs, as guiding premise, will help us to develop much safer NCs and also to accelerate their translation into clinical use and to provide pivotal information on safety liabilities early in discovery and developments process prior to its inevitable consequences in vivo.
dc.language.isoEnglish
dc.relation.ispartofBioImpacts : BI
dc.titleIntrinsic bio-signature of gene delivery nanocarriers may impair gene therapy goals.
dc.typearticle
dc.citation.volume3
dc.citation.issue3
dc.citation.spage105
dc.citation.epage9
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.5681/bi.2013.028


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