Show simple item record

dc.contributor.authorKhademi, F
dc.contributor.authorDanesh, B
dc.contributor.authorMohammad Nejad, D
dc.contributor.authorSoleimani Rad, J
dc.date.accessioned2018-08-26T06:05:38Z
dc.date.available2018-08-26T06:05:38Z
dc.date.issued2013
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/41819
dc.description.abstractThis study investigates the ability of quince leaf extract to prevent progression of atherosclerosis and to determine the lipid-lowering effect of it.This study suggested that quince leaf effects on progression of atherosclerosis, and performed comparison with atorvastatin as a standard medication.The effect of 50mg/kg of the quince leaf extract on lipid profiles was assessed by measuring the levels of totalcholesterol, triglyceride, LDL, HDL, and liver enzymes (AST, ALT, and AP) in plasma and were evaluated the thickness of aortic plaques in the hypercholesterolemic rabbits after stopping. These assessments were performed using 0.5 mg/kg of atorvastatin.Oral administration of cholesterol for 8 weeks resulted in a significant increase (P < 0.05) in plasma markers. Treatment with the extract at dose of 50 mg/kg and 0.5 mg/kg of atorvastatin not only were reduced lipid profile in plasma (P < 0.05) but also were increased HDL-cholesterol levels. There were decrease (P = 0.04) in the liver enzymes in extract treated rabbits. However, plaque thickness had no significant difference in the aorta of treated rabbits compared with studied control.These results indicate the lipid-lowering effects of quince leaf similar to atorvastatin and it can probably serve as a new potential natural product for atherosclerosis treatment.
dc.language.isoEnglish
dc.relation.ispartofIranian Red Crescent medical journal
dc.titleThe comparative effects of atorvastatin and quince leaf extract on atherosclerosis.
dc.typearticle
dc.citation.volume15
dc.citation.issue8
dc.citation.spage639
dc.citation.epage43
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.5812/ircmj.4030


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record