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dc.contributor.authorToufan, M
dc.contributor.authorNamdar, H
dc.contributor.authorAbbasnezhad, M
dc.contributor.authorHabibzadeh, A
dc.contributor.authorEsmaeili, H
dc.contributor.authorYaraghi, S
dc.contributor.authorSamani, Z
dc.date.accessioned2018-08-26T06:04:43Z
dc.date.available2018-08-26T06:04:43Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/41553
dc.description.abstractThe plasma N-terminal probrain natriuretic peptide (NT-proBNP) level is an important diagnostic and prognostic marker of heart failure. Recent studies have suggested urinary NT-proBNP as a new and simple test for diagnosis of heart failure. We aim to compare diagnostic value of plasma, fresh and frozen urine levels of N-terminal probrain natriuretic peptide (NT-proBNP) for detecting heart failure.Between January 2010 and January 2012, we measured urine and plasma levels of NTproBNP in 98 patients with chronic heart failure (CHF) and 29 age- and sex-matched healthy control subjects.There were significant correlations between plasma NT-proBNP and fresh (r=0.45, p<0.001) and frozen (r=0.42, p<0.001) urine NT-proBNP concentrations in CHF patients. Due to receiver operating curve analysis, fresh and frozen urine NT-proBNP could diagnose HF with are aunder curve (AUC) of 0.73آ±0.04 (p<0.001) and 0.65آ±0.05 (p=0.01) with sensitivity and specificity of 73.97%, 58.62%, and 65.31%, 62.07%, for a cut-off of 94.2 and 96 pg/mL, respectively. Plasma NT-proBNP had greater AUC (0.94آ±0.02, p<0.001) and better sensitivity and specificity (94.9%, 89.66% for cut-off of 414.5 pg/mL). There was no significant correlation between LVEF and plasma, fresh and frozen urine NT-proBNP levels in CHF patients.Plasma NT-proBNP is still the best diagnostic marker with high sensitivity and specificity; however, urinary especially fresh urine NT-proBNP may be a surrogate to plasma NTproBNP for diagnosing HF with acceptable accuracy.
dc.language.isoEnglish
dc.relation.ispartofJournal of cardiovascular and thoracic research
dc.titleDiagnostic Values of Plasma, Fresh and Frozen Urine NT-proBNP in Heart Failure Patients.
dc.typearticle
dc.citation.volume6
dc.citation.issue2
dc.citation.spage111
dc.citation.epage5
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.5681/jcvtr.2014.024


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