نمایش پرونده ساده آیتم

dc.contributor.authorHomayouni, A
dc.contributor.authorSadeghi, F
dc.contributor.authorVarshosaz, J
dc.contributor.authorAfrasiabi Garekani, H
dc.contributor.authorNokhodchi, A
dc.date.accessioned2018-08-26T06:04:34Z
dc.date.available2018-08-26T06:04:34Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/41492
dc.description.abstractPoor solubility and dissolution of hydrophobic drugs have become a major challenge in pharmaceutical development. Drug nanoparticles have been widely accepted to overcome this problem. The aim of this study was to manufacture celecoxib nanoparticles using antisolvent precipitation and high pressure homogenization techniques in the presence of varying concentrations of soluplus(®) as a hydrophilic stabilizer. Antisolvent crystallization followed by freeze drying (CRS-FD) and antisolvent crystallization followed by high pressure homogenization and freeze drying (HPH-FD) were used to obtain celecoxib nanoparticles. The obtained nanoparticles were analyzed in terms of particle size, saturation solubility, morphology (optical and scanning electron microscopy), solid state (DSC, XRPD and FT-IR) and dissolution behavior. The results showed that celecoxib nanoparticle can be obtained when soluplus was added to the crystallization medium. In addition, the results showed that the concentration of soluplus and the method used to prepare nanoparticles can control the size and dissolution of celecoxib. Samples obtained in the presence of 5% soluplus through HPH technique showed an excellent dissolution (90%) within 4min. It is interesting to note that celecoxib samples with high crystallinity showed better dissolution than those celecoxib samples with high amorphous content, although they had the same concentration of soluplus. DSC and XRPD proved that samples obtained via HPH technique are more crystalline than the samples obtained through only antisolvent crystallization technique.
dc.language.isoEnglish
dc.relation.ispartofColloids and surfaces. B, Biointerfaces
dc.subjectCalorimetry, Differential Scanning
dc.subjectCelecoxib
dc.subjectCrystallization
dc.subjectNanoparticles
dc.subjectParticle Size
dc.subjectPolyethylene Glycols
dc.subjectPolyvinyls
dc.subjectPowder Diffraction
dc.subjectPressure
dc.subjectPyrazoles
dc.subjectSolubility
dc.subjectSolvents
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.subjectSulfonamides
dc.titlePromising dissolution enhancement effect of soluplus on crystallized celecoxib obtained through antisolvent precipitation and high pressure homogenization techniques.
dc.typearticle
dc.citation.volume122
dc.citation.spage591
dc.citation.epage600
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1016/j.colsurfb.2014.07.037


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