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dc.contributor.authorEzzati Nazhad Dolatabadi, J
dc.contributor.authorHamishehkar, H
dc.contributor.authorValizadeh, H
dc.date.accessioned2018-08-26T06:04:25Z
dc.date.available2018-08-26T06:04:25Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/41437
dc.description.abstractAlendronate sodium is a bisphosphonate drug used for the treatment of osteoporosis and acts as a specific inhibitor of osteoclast-mediated bone resorption. Inhalable solid lipid nanoparticles (SLNs) of the alendronate were successfully designed and developed by spray-dried and co-spray dried inhalable mannitol from aqueous solution. Emulsification technique using a simple homogenization method was used for preparation of SLNs. In vitro deposition of the aerosolized drug was studied using a Next Generation Impactor at 60?L/min following the methodology described in the European and United States Pharmacopeias. The Carr's Index, Hausner ratio and angle of repose were calculated as suitable criteria for estimation of the flow behavior of solids. Scanning electron microscopy showed spherical particle morphology of the respirable particles. The proposed spray-dried nanoparticulate-on-microparticles dry powders displayed good aerosol dispersion performance as dry powder inhalers with high values in emitted dose, fine particle fraction and mass median aerodynamic diameter. These results indicate that this novel inhalable spray-dried nanoparticulate-on-microparticles aerosol platform has great potential in systemic delivery of the drug.
dc.language.isoEnglish
dc.relation.ispartofDrug development and industrial pharmacy
dc.subjectAdministration, Inhalation
dc.subjectAerosols
dc.subjectAlendronate
dc.subjectBone Density Conservation Agents
dc.subjectChemistry, Pharmaceutical
dc.subjectDrug Compounding
dc.subjectDrug Delivery Systems
dc.subjectDry Powder Inhalers
dc.subjectLipids
dc.subjectMannitol
dc.subjectMicroscopy, Electron, Scanning
dc.subjectNanoparticles
dc.titleDevelopment of dry powder inhaler formulation loaded with alendronate solid lipid nanoparticles: solid-state characterization and aerosol dispersion performance.
dc.typearticle
dc.citation.volume41
dc.citation.issue9
dc.citation.spage1431
dc.citation.epage7
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.3109/03639045.2014.956111


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