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dc.contributor.authorMofarrah, M
dc.contributor.authorZiaee, S
dc.contributor.authorPilehvar-Soltanahmadi, Y
dc.contributor.authorZarghami, F
dc.contributor.authorBoroumand, M
dc.contributor.authorZarghami, N
dc.date.accessioned2018-08-26T05:37:51Z
dc.date.available2018-08-26T05:37:51Z
dc.date.issued2016
dc.identifier10.1097/MCA.0000000000000386
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/39949
dc.description.abstractRecently, several genes have been introduced as potential genetic markers for diabetes mellitus and coronary artery diseases (CAD).In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of KALRN, and rs9939609 A/T of FTO polymorphisms with genetic susceptibility to CAD in type 2 diabetic (T2D) patients were investigated. A total of 224 T2D patients undergoing coronary angiography were randomly recruited into the study. Of the total diabetic patients, 152 were also diagnosed with CAD, whereas the rest were control participants. Genotyping of single-nucleotide polymorphisms was performed by high-resolution melting analysis.Genotype analysis showed that the minor allele (G) frequency of rs2241766 ADIPOQ was statistically significant in the CAD group compared with the control group [odds ratio (OR), 2.779; 95% confidence interval (CI), 1.403-5.504; P=0.003]. Also, it was found that the minor allele (G) frequency of rs9289231 KALRN was significantly associated with the risk of CAD (OR, 2.098; 95% CI, 1.096-4.017; P=0.025). In addition, no significant association was observed between the minor allele (A) of the FTO rs9939609 polymorphism and CAD (OR, 1.088; 95% CI, 0.578-2.015; P=0.788). It is speculated that the GG genotype and the G allele of the rs9289231 polymorphism of KALRN and the rs224766 polymorphism of ADIPOQ genes may be considered genetic risk factors for CAD in T2D patients and genetic variations of these genes may play a major role in the process of these disorders.Our case-control study in the Iranian population suggested a possible association between the mentioned single-nucleotide polymorphisms and CAD in T2D patients. However, further replication studies and comprehensive meta-analyses are required.
dc.language.isoEnglish
dc.relation.ispartofCoronary artery disease
dc.subjectAdiponectin
dc.subjectAged
dc.subjectAlpha-Ketoglutarate-Dependent Dioxygenase FTO
dc.subjectCase-Control Studies
dc.subjectChi-Square Distribution
dc.subjectCoronary Angiography
dc.subjectCoronary Artery Disease
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetic Angiopathies
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectGuanine Nucleotide Exchange Factors
dc.subjectHumans
dc.subjectIran
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectOdds Ratio
dc.subjectPhenotype
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Single Nucleotide
dc.subjectProtein-Serine-Threonine Kinases
dc.subjectRisk Factors
dc.titleAssociation of KALRN, ADIPOQ, and FTO gene polymorphism in type 2 diabetic patients with coronary artery disease: possible predisposing markers.
dc.typearticle
dc.citation.volume27
dc.citation.issue6
dc.citation.spage490
dc.citation.epage6
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1097/MCA.0000000000000386


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