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dc.contributor.authorAslani, S
dc.contributor.authorJafari, N
dc.contributor.authorJavan, MR
dc.contributor.authorKarami, J
dc.contributor.authorAhmadi, M
dc.contributor.authorJafarnejad, M
dc.date.accessioned2018-08-26T05:37:21Z
dc.date.available2018-08-26T05:37:21Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/39839
dc.description.abstractBreakthroughs in genetic studies, like whole human genome sequencing and genome-wide association studies (GWAS), have richened our knowledge of etiopathology of autoimmune diseases (AID) through discovery of genetic patterns. Nonetheless, the precise etiology of autoimmune diseases remains largely unknown. The lack of complete concordance of autoimmune disease in identical twins suggests that non-genetic factors also play a major role in determining disease susceptibility. Although there is no certain definition, epigenetics has been known as heritable alterations in gene function without changes in the nucleotide sequence. DNA methylation, histone modifications, and microRNA-associated gene expression suppression are the central mechanisms for epigenetic regulations. Multiple sclerosis (MS) is a disorder of the central nervous system (CNS), characterized by both inflammatory and neurodegenerative features. Although studies on epigenetic alterations in MS only began in the past decade, a mounting number of surveys suggest that epigenetic changes may be involved in the initiation and development of MS, probably through bridging the effects of environmental risk factors to genetics. Arming with clear understanding of epigenetic dysregulations underpins development of epigenetic therapies. Identifying agents inhibiting the enzymes controlling epigenetic modifications, particularly DNA methyltransferases and histone deacetylases, will be promising therapeutic tool toward MS. In the article underway, it is aimed to go through the recent progresses, attempting to disclose how epigenetics associates with the pathogenesis of MS and how can be used as therapeutic approach.
dc.language.isoEnglish
dc.relation.ispartofNeuromolecular medicine
dc.subjectAnimals
dc.subjectDNA Methylation
dc.subjectDiseases in Twins
dc.subjectEncephalomyelitis, Autoimmune, Experimental
dc.subjectEnzyme Inhibitors
dc.subjectEpigenesis, Genetic
dc.subjectFemale
dc.subjectGene Expression Regulation
dc.subjectGene-Environment Interaction
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Therapy
dc.subjectGenetic Vectors
dc.subjectGenome-Wide Association Study
dc.subjectHistone Code
dc.subjectHistone Deacetylase Inhibitors
dc.subjectHumans
dc.subjectMale
dc.subjectMicroRNAs
dc.subjectMultiple Sclerosis
dc.subjectRisk Factors
dc.titleEpigenetic Modifications and Therapy in Multiple Sclerosis.
dc.typearticle
dc.citation.volume19
dc.citation.issue1
dc.citation.spage11
dc.citation.epage23
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1007/s12017-016-8422-x


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