| dc.description.abstract | The evidence in support of the effect of vitamin D deficiency on cardiovascular diseases is inconsistent. The objective of this randomized, controlled, double-blind study was to assess the effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome.Eighty subjects were randomized to receive 50,000آ IU vitamin D or matching placebo weekly for 16آ weeks. Fasting blood sugar, homeostasis model assessment of insulin resistance, insulin sensitivity (Quicki), serum lipid profiles (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride (TG) and total cholesterol), anthropometric factors and blood pressure were assessed before and after intervention. Dietary intake and sun exposure were also determined. The trial was registered at http://www.irct.ir (code: IRCT201409033140N14).Participants were 40.49آ آ±آ 5.04آ years and 49آ % male. All of the intervention group and 97آ % of placebo group were vitamin D deficient or insufficient (25-hydroxyvitamin D <75آ nmol/L). After intervention, serum 25(OH)D concentration was increased by 61.93آ nmol/L in intervention group, while it was decreased in placebo group (pآ <آ 0.001). There was a significant change in TG concentration after 4آ months (pآ <آ 0.001). Other metabolic or anthropometric factors did not change significantly (pآ =آ 0.05).Supplementation with high-dose vitamin D for 4آ months improved vitamin D status and decreased TG levels in subjects with metabolic syndrome. However, it did not have any beneficial effects on other cardiometabolic risk factors; this might be due to the inadequate vitamin D status attained in this study which was conducted in a severely deficient region. | |
