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dc.contributor.authorZaare Nahandi, M
dc.contributor.authorArdalan, MR
dc.contributor.authorBanagozar Mohamadi, A
dc.contributor.authorGhorbani Haghjo, A
dc.contributor.authorJabbarpor Bonyadi, M
dc.contributor.authorMohamadian, T
dc.date.accessioned2018-08-26T05:02:14Z
dc.date.available2018-08-26T05:02:14Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/39102
dc.description.abstractThe kidney is the main source of serum Klotho production. Immunosuppressive agents could affect the kidney in this regard. The effect of the ACE gene polymorphism on Klotho production is a less studied area. This study aimed to assess serum Klotho and ACE gene in a group of stable kidney transplant recipients.In a cross-sectional study, 30 kidney transplant recipients with stable allograft function and 27 healthy young individuals were assessed for their serum Klotho levels. The ACE gene polymorphisms were studied in both groups.Klotho level was higher in kidney transplant recipients than the controls, but the difference was not significant (2.76 ± 2.41 ng/mL versus 2.01 ± 1.41 ng/mL, respectively). In both groups, serum Klotho level was higher in those with the I>I polymorphism, the men, those with higher glomerular filtration rate, and younger individuals, but the differences did not reach a significant level. Higher body mass index was significantly associated with lower serum Klotho level in both groups.Klotho level after kidney transplantation meets the range in healthy individuals, and it is not affected by the ACE gene polymorphism.
dc.language.isoEnglish
dc.relation.ispartofIranian journal of kidney diseases
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectGlomerular Filtration Rate
dc.subjectGlucuronidase
dc.subjectHumans
dc.subjectImmunosuppressive Agents
dc.subjectIran
dc.subjectKidney
dc.subjectKidney Transplantation
dc.subjectMale
dc.subjectPeptidyl-Dipeptidase A
dc.subjectPolymorphism, Genetic
dc.subjectYoung Adult
dc.titleRelationship of Serum Klotho Level With ACE Gene Polymorphism in Stable Kidney Allograft Recipients.
dc.typearticle
dc.citation.volume11
dc.citation.issue2
dc.citation.spage151
dc.citation.epage156
dc.citation.indexPubmed


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