نمایش پرونده ساده آیتم

dc.contributor.authorLlona-Minguez, S
dc.contributor.authorH?glund, A
dc.contributor.authorGhassemian, A
dc.contributor.authorDesroses, M
dc.contributor.authorCalder?n-Monta?o, JM
dc.contributor.authorBurgos Mor?n, E
dc.contributor.authorValerie, NCK
dc.contributor.authorWiita, E
dc.contributor.authorAlml?f, I
dc.contributor.authorKoolmeister, T
dc.contributor.authorMateus, A
dc.contributor.authorCazares-K?rner, C
dc.contributor.authorSanjiv, K
dc.contributor.authorHoman, E
dc.contributor.authorLoseva, O
dc.contributor.authorBaranczewski, P
dc.contributor.authorDarabi, M
dc.contributor.authorMehdizadeh, A
dc.contributor.authorFayezi, S
dc.contributor.authorJemth, AS
dc.contributor.authorWarpman Berglund, U
dc.contributor.authorSigmundsson, K
dc.contributor.authorLundb?ck, T
dc.contributor.authorJenmalm Jensen, A
dc.contributor.authorArtursson, P
dc.contributor.authorScobie, M
dc.contributor.authorHelleday, T
dc.date.accessioned2018-08-26T04:59:52Z
dc.date.available2018-08-26T04:59:52Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/38890
dc.description.abstractThe dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. We have identified a series of piperazin-1-ylpyridazines as a new class of potent dCTPase inhibitors. Lead compounds increase dCTPase thermal and protease stability, display outstanding selectivity over related enzymes and synergize with a cytidine analogue against leukemic cells. This new class of dCTPase inhibitors lays the first stone toward the development of drug-like probes for the dCTPase enzyme.
dc.language.isoEnglish
dc.relation.ispartofJournal of medicinal chemistry
dc.subjectAntineoplastic Agents
dc.subjectCell Line, Tumor
dc.subjectCell Survival
dc.subjectEnzyme Inhibitors
dc.subjectHumans
dc.subjectLeukemia
dc.subjectMolecular Docking Simulation
dc.subjectPiperazines
dc.subjectPyridazines
dc.subjectPyrophosphatases
dc.titlePiperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
dc.typearticle
dc.citation.volume60
dc.citation.issue10
dc.citation.spage4279
dc.citation.epage4292
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1021/acs.jmedchem.7b00182


فایلهای درون آیتم

فایلهاسایزفرمتنمایش

هیچ فایل مرتبطی وجود ندارد

این آیتم در مجموعه های زیر مشاهده می شود

نمایش پرونده ساده آیتم