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dc.contributor.authorAfrasiabi Garekani, H
dc.contributor.authorSanadgol, N
dc.contributor.authorDehghan Nayyeri, N
dc.contributor.authorNokhodchi, A
dc.contributor.authorSadeghi, F
dc.date.accessioned2018-08-26T04:55:49Z
dc.date.available2018-08-26T04:55:49Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/38409
dc.description.abstractPlasticizers play a crucial role in various process of microencapsulation. In this study, the effect of incorporation of plasticizer in process of emulsion solvent evaporation was investigated on properties of ethyl cellulose (EC) microcapsules containing propranolol hydrochloride. The effect of plasticizer type and concentration were investigated on characteristics of microcapsules prepared from different viscosity grades of EC. Product yield, encapsulation efficiency, mean particle size, shape, surface characteristics, solid state of drug, and drug release profiles were evaluated. Product yield and encapsulation efficiency were not dependent on plasticizer type and concentration. However, encapsulation efficiency decreased with increase in EC viscosity grade in the most of the cases. The mean particle size was in the range of 724-797??m and was not dependent on plasticizer type. Microcapsules formed in the presence of PEG had a very smooth surface with few pores. XRD and DSC studies revealed a reduction of drug crystallinity after microencapsulation especially in presence of PEG. The results showed that the presence of TEC and DEP with different concentrations had no marked effect on drug release from microcapsules containing different viscosity grades of EC. This was not the case when PEG was used, and despite its water solubility it reduced the drug release rate noticeably. The reduction in the drug release in the presence of PEG was concentration-dependent. The use of PEG as a plasticizer in process of emulsion solvent evaporation highly improved the EC microcapsule structure and retarded the drug release rate and therefore is recommended.
dc.language.isoEnglish
dc.relation.ispartofDrug development and industrial pharmacy
dc.subjectCapsules
dc.subjectCellulose
dc.subjectCitrates
dc.subjectDrug Compounding
dc.subjectEmulsions
dc.subjectParticle Size
dc.subjectPhthalic Acids
dc.subjectPlasticizers
dc.subjectPolyethylene Glycols
dc.subjectPropranolol
dc.subjectSolubility
dc.subjectSolvents
dc.subjectViscosity
dc.titlePeculiar effect of polyethylene glycol in comparison with triethyl citrate or diethyl phthalate on properties of ethyl cellulose microcapsules containing propranolol hydrochloride in process of emulsion-solvent evaporation.
dc.typearticle
dc.citation.volume44
dc.citation.issue3
dc.citation.spage421
dc.citation.epage431
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1080/03639045.2017.1395460


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