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dc.contributor.authorNejati-Azar, A
dc.contributor.authorAlivand, MR
dc.date.accessioned2018-08-26T04:52:44Z
dc.date.available2018-08-26T04:52:44Z
dc.date.issued2018
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/37667
dc.description.abstractThe purpose of our study was to analyze association of miRNAs 146aG/C(2910164) and 196a2C/T(11614913) polymorphism with breast cancer (BC) risk for women of Azeri ethnicity in Iran.In the current case (n =آ 200)-control (n =آ 200) study, miRNAs 146aG/C(2910164) and 196a2C/T(11614913) were investigated for allelic and genotypic levels via the PCR-restriction fragment length polymorphism technique.The statistical analysis showed a significant relation between CC genotype of rs11614913(196a2) (codominant, odds ratio (OR) =آ 0.58, pآ =آ 0.02236; recessive, ORآ =آ 2.92, pآ =آ 0.01695; overdominant, ORآ =آ 0.44, pآ =آ 0.0113) and BC susceptibility. The subgroup analysis of mentioned polymorphism declared the significant correlation (pآ ?آ 0.05) of the positive abortion, regular menstruation, positive human epidermal receptor-2 and positive estrogen receptor with BC susceptibility in CC genotype.The existence of a C-allele at miRNA 196a2(11614913) elevates women's BC susceptibility in Azeri ethnicity in Iran.
dc.language.isoEnglish
dc.relation.ispartofPersonalized medicine
dc.titlemiRNA 196a2(rs11614913)آ &آ 146a(rs2910164) polymorphisms & breast cancer risk for women in an Iranian population.
dc.typearticle
dc.citation.volume15
dc.citation.issue4
dc.citation.spage279
dc.citation.epage289
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.2217/pme-2017-0088


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