بررسی اثر عوامل مختلف بر روی انحلال داروهای نامحلول از پراکندگی های جامد

Abstract

The purpose of this study was to prepare and characterize solid dispersions of indomethacin and piroxicam with polyethylene glycoles, Myrj 52, Eduragit E100 and different carbohydrates such as lactose, mannitol, sorbitol and dextrin. Indomethacin and piroxicam are class II substances according to the Biopharmaceutics classification system. they are poorly water soluble anti rheumatic agents. The goal was to investigate whether the solid dispersion were prepared by tree different methods depending on the type of carrier. The evaluation of the properties of the dispersions was performed using solubility measurments, dissolution studies, Fouriertransform infrared spectroscopy and Xray powder diffractometery. The results indicate that lactose, Mannitol and specially Myrj 52 are suitable carriers to enhance the in vitro dissolution rate of indomethacin and piroxicam at PH 7.2 Eudragit E100, Myrj 52 and mannitol increase the dissolution properties at PH 1.2. The data from the Xray diffraction showed that these drugs were still detectable in their solid state in some of the solid dispersions. But some crystal changes occurred in solid dispersions with dextrin and mannitol. However, the result from infrared spectroscopy together with those from Xray diffraction showed well defined drugcarrier interactions for some preparations.