Published Articles: Recent submissions
Now showing items 481-500 of 13578
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Synthesis of four new 3-imidazolyl-2-azidoacrylate derivatives bearing biphenyl tetrazole moiety as potential angiotensin II receptor antagonist
(2013)Background: The renin angiotensin system which is stimulated by angiotensin II, leads to increase in blood pressure. An angiotensin II receptor antagonist can control effectively hypertension. Synthesis of new compounds ... -
Synthesis of graphene oxide supported copperأ¢â‚¬â€œcobalt ferrite material functionalized by arginine amino acid as a new highأ¢â‚¬â€œperformance catalyst
(2018)A novel Cu0.5Co0.5Fe2O4@Argأ¢â‚¬â€œGO catalytic system was successfully prepared by immobilization of copper substituted cobalt ferrite nanoparticles on arginineأ¢â‚¬â€œgrafted graphene oxide nanosheets, in which ferrite ... -
Synthesis and physicochemical evaluation of novel smart polymer for ocular drug delivery of anti-inflammatory drugs
(2011)Objectives: The purpose of this study was synthesis of a novel smart copolymer and evaluation of its physicochemical characteristics as a suitable nano-carrier for ophthalmic drug delivery of anti-inflammatory drugs. ... -
Synthesis and investigation of magnetic nanocomposite of Fe 3O4 with cetirizine-intercalated layered double hydroxide
(2014)In this research work the nanocomposite CT-LDH/Fe3O4 was prepared by deposition of cetirizine (CT) intercalated-Mg-Al layered double hydroxide (LDH) on Fe3O4 using a co-precipitation method for sustained drug-targeting ... -
Synthesis and in vitro study of cisplatin-loaded Fe<inf>3</inf>O<inf>4</inf> nanoparticles modified with PLGA-PEG<inf>6000</inf> copolymers in treatment of lung cancer
(2014)In the field of cancer therapy, magnetic nanoparticles modified with biocompatible copolymers are promising vehicles for the delivery of hydrophobic drugs such as Cisplatin. The major aim of this effort was to evaluate ... -
Synthesis and Evaluation of a Triblock Copolymer/ZnO Nanoparticles from Poly(?-caprolactone) and Poly(Acrylic Acid) as a Potential Drug Delivery Carrier
(2017)Through the present paper, a triblock copolymer containing pH-responsive (polyacrylic acid-b-polycaprolactone -b-polyacrylic acid) (PAA-b-PCL-b-PAA) was synthesized by using the ring-opening polymerization (ROP) of ... -
Synthesis and cytotoxicity evaluation of some novel 1-(3-Chlorophenyl) piperazin-2-one derivatives bearing imidazole bioisosteres
(2013)A series of substituted 3-chlorophenylpiperazinone derivatives were synthesised using L-778123 (an imidazole-containing FTase inhibitor) as a model by bioisosteric replacement of the imidazole ring. The final compounds ... -
Synthesis and characterization of two copper (II) complexes of 4?-tolyl-2,2?:6?,2?-terpyridine and simultaneous detection and separation of [Cu(ttpy)(NO3)2] and CuO by capillary zone electrophoresis method
(2015)A simple synthetic method has been used to prepare copper(II) complexes of 4?-tolyl-2,2?:6?,2?-terpyridine (ttpy) ligand, [Cu(ttpy) (NO3)2] (1) and [Cu2(ttpy)(ClO4)4]n (2), in good yields. Also capillary zone electrophoresis ... -
Synthesis and characterization of thermosensitive and pH-sensitive poly (N-isopropylacrylamide-acrylamide- vinylpyrrolidone) for use in controlled release of naltrexone
(2009)In this article N-isopropylacrylamide (NIPAAm)- acrylamide (AAm)-vinyl pyrrolidone (VP) terpolymers were prepared using free radical copolymerization method by varying feed ratios of monomers. The composition ratio and ... -
Synthesis and characterization of PVP-functionalized superparamagnetic Fe 3O 4 nanoparticles as an MRI contrast agent
(2010)The magnetite (Fe 3O 4) nanoparticles (MNPs) coated with poly(N-vinyl pyrrolidone) (PVP) via covalent bonds were prepared as T 2 contrast agent for magnetic resonance imaging (MRI). The surface of MNPs was first coated ... -
Synthesis and characterization of methacrylic derivatives of 5-amino salicylic acid with pH-sensitive swelling properties
(2001)The purpose of this study is to develop novel colon-specific drug delivery systems with pH-sensitive swelling and drug release properties. Methacrylic-type polymeric prodrugs with different content levels of 5-amino salicylic ... -
Synthesis and cellular characterization of various nano-assemblies of cell penetrating peptide-epirubicin-polyglutamate conjugates for the enhancement of antitumor activity
(2017)A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the antitumor activity of epirubicin (EPR). Various amphiphilic CPPs were synthesized by solid ... -
Synthesis and anti-leishmanial activity of 5-(5-nitrofuran-2-yl)-1,3,4- thiadiazol-2-amines containing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moieties
(2012)A novel series of 5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amines were synthesized by introducing N-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] moiety as a new functionality on the C-2 amine of thiadiazole ring via click ... -
Synthesis and antibacterial activity of silver nanoparticles embedded in smart poly(n-isopropylacrylamide)-based hydrogel networks
(2011)In recent study, we report the synthesis and antibacterial activity of silver nanoparticles embedded in smart poly(N-isopropylacrylamide)-based hydrogel networks. A series of thermosensitive poly(N-isopropylacrylamide- ... -
Synergistic growth inhibitory effects of Chrysin and Metformin combination on breast cancer cells through hTERT and cyclin D1 suppression
(2018)Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment, the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast ... -
Synergistic effects of resistin and visfatin as adipocyte derived hormones on telomerase gene expression in AGS gastric cancer cell line
(2017)Recently suggested that adipocytokines may play a role in pathogenesis and progression of certain cancers, especially in gastric cancer. The previous study showed Resistin and Visfatin, as adipocyte derived hormones, ... -
Synergistic effect of persica mouthwash and Iranian ethanolic extract of propolis against biofilm formation of oral pathogens (in vitro study)
(2017)Aims: Several pathogens are responsible for oral diseases and dental plaque and their main mechanism is biofilm production. Natural products are point of interest for controlling these infections. persica mouthrinse, ... -
Synergistic Anti-proliferative Effects of Metformin and Silibinin Combination on T47D Breast Cancer Cells via hTERT and Cyclin D1 Inhibition
(2018)Background There is a growing body of data that chemotherapeutic combination strategies would be more effective in reducing drug toxicity, inhibiting tumor progression in comparison to either drug alone. Objective To explore ... -
Synergistic anticancer effects of silibinin and chrysin in T47D breast cancer cells
(2017)Objective: Breast cancer is one of the most significant causes of female cancer death worldwide. Although several chemotherapeutics have been developed to treat this type of cancer, issues remain such as low survival rates ... -
Swimming exercise induced reversed expression of miR-96 and its target gene NaV1.3 in diabetic peripheral neuropathy in rats
(2018)Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy (DPN). Recently, the role of micro-ribonucleic acid-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, ...