dc.description.abstract | Introduction: Congestive heart failure (CHF) is a common problem and its prevalence is increasing in industrialized countries, In addition, CHF has a large economic burden and can affect the person's quality of life, thus, early diagnosis and immediate treatment is necessary to prevent patients disease progression and disability. One of the proven methods for the diagnosis of heart failure in people with acute dyspnea is serum NT-proBNP measurement. The aim of this study is to determine the relationship between levels of brain natriuretic peptide precursor and the degree lung function impairment in patients with chronic congestive heart failure. Methods: This cross-sectional and analytical study performed in Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences on 95 patients with chronic heart failure and the relation between serum NT-proBNP levels and pulmonary function parameters were studied. Results: 64 of patients were male and 31 were female. The mean age of males was 62.911.54 and mean age of females was 61.6111.98. Significant inverse linear correlation was found between NT-proBNP and EF of patients. A significant inverse linear correlation was found between NT-proBNP and FEV1, FVC, TLC and MMEF. A significant positive linear correlation was found between NT-proBNP with FEV1/FVC, RV / TLC and Raw 5 Htz. A significant positive linear correlation was found between EF with FEV1, FVC and MMEF . A significant inverse linear correlation was found between EF with Raw5Htz. A significant linear correlation was not found between NT-proBNP and RV, ITGV / TLC and Raw 20 Htz.,
هدف از این مطالعه تعیین ارتباط سطح پیشساز پپتید ناتریورتیک مغزی با شدت اختلال عملکرد ریه در بیماران نارسایی احتقانی مزمن قلبی است.مواد و روشها:این مطالعه مقطعی توصیفی- تحلیلی در مرکز تحقیقات سل و بیماریهای ریوی دانشگاه علوم پزشکی تبریز بر روی 95 بیمار دچار نارسایی قلبی مزمن انجام شد و ارتباط بین سطح NT-proBNP و پارامترهای عملکرد ریوی مورد بررسی قرار گرفت.نتایج: 64 نفر از بیماران مرد و 31 نفر زن بودند. میانگین سنی بیماران مرد 54/11 90/62 سال و میانگین سنی بیماران زن 98/11 61/61 سال بود. رابطه خطی معنی دار معکوسی بین NT-proBNP با میزان EF بیماران وجود داشت. رابطه خطی معنی دار معکوسی بین NT-proBNP با FEV1، FVC ، TLC و MMEF وجود داشت. رابطه خطی معنی دار مستقیمی بین NT-proBNP با FEV1/FVC ، RV/TLC و Raw 5 Htz بیماران وجود داشت. رابطه خطی معنی دار مستقیمی بین EF با میزان FEV1 ،FVC ،MMEF و رابطه خطی معنی دار معکوسی بین EF با Raw 5 Htz بیماران وجود داشت. رابطه خطی معنی داری بین NT-proBNP با RV ، میزان ITGV ، میزان ITGV/TLC و میزان Raw 20 Htz بیماران وجود نداشت. | |