Comparison of macrophage density in various odontogenic cysts and benign odontogenic tumors

Abstract

Macrophages have been the target of attention in numerous diseases. Many studies has reported that macrophages are regulators of the growth, dissemination and clinical behaviorof various lesions. Relatively scarce data regarding the role of macrophages in oral lesions, particularly odontogenic lesions is available.Therefore, we investigated macrophages in odontogeniclesionsof diverse biologic performance. Aim: The aim of this study was to represent a step forward in understanding the pathobiology and the potential relationship between macrophages and the diverse clinical behavior of odontogenic lesions. Materials and Methods: samples of odontogenic lesions including cases of ameloblastoma, cases of odontogenickeratocyst, cases of dentigerous cyst, and cases of radicular cyst were evaluated in this stydy. The samples were immunohistochemically stained with anti-CD antibody. Five hot spot field were selected and the quantitative evaluations were performed at a magnification of . Apparently stained CD-positive cells were counted in each high power field and the mean of five fields was considered as macrophage density for that case. Results: Our results showed that macrophage density did not differ significantly amongst the groups except for radicular cyst (p<.). Conclusion: Development is a complex process involvingnumerous factorsand our results do not support macrophages as a contributing factor in the local aggressiveness of odontogenic lesionsof diverse biologic performance.