Theoretical modeling of oral absorption of barbiturates

Abstract

The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption. (C) 2002 tditions scientifiques et medicales Elsevier SAS. All rights reserved.