Evaluation of Fc?RIIIB-NA1/NA2 Polymorphism in Visceral Leishmaniasis
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Background: Several lines of evidence demonstrating that innate and adaptive immunity play important roles in the defense against visceral leishmaniasis (VL). A polymorphism within the Fc?RIIIB gene can lead to the expression of three variants of NA1, NA2, and the combined one (NA1/NA2) which alters affinity of IgG to its receptor.
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Fc gamma receptor IIIb NA1, Fc gamma receptor IIIb NA2, immunoglobulin receptor, unclassified drug, allele, antibody titer, article, binding affinity, controlled study, cross-sectional study, DNA sequence, female, genetic polymorphism, genotype, human, immune response, immunofluorescence test, major clinical study, male, polymerase chain reaction, visceral leishmaniasis