Solubility of salbutamol and salbutamol sulphate in ethanol plus water mixtures at 25 degrees C

Abstract

Experimental solubilities of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25 degrees C are reported. The solubility of salbutamol was found to increase with the addition of ethanol, and reached a maximum value at an ethanol volume fraction of 0.8. The solubility of salbutamol sulphate decreased with increasing ethanol concentration, and reached a minimum value in ethanol. The Jouyban-Acree model correlated the measured salbutamol and salbutamol sulphate solubility data to within mean relative deviations (MRD) of 3.4% and 13.4%, respectively. Solubilities were predicted using previously trained models developed for crystalline non-electrolyte and electrolyte solutes. The trained models for non-electrolytes and electrolytes produced the prediction MRDs of 22.4% and 19.8%, respectively. (C) 2012 Elsevier B.V. All rights reserved.