Study of essential trace element; Selenium (Se), manganese (Mn), copper (Cu), zinc (Zn) in COVID- 19 patients

Abstract

Micronutrients - including vitamins and trace elements - are considered as one of the inhibitory factors in the prevention of diseases due to their various antioxidant effects. The aim of this study was to evaluate serum levels of zinc, copper, selenium, manganese and in patients with COVID-19. Methods: In this prospective, prospective observational study, we included 114 patients admitted to the intensive care unit (ICU) and 112 non-ICU patients who were unified in terms of gender and age. Demographic information, clinical profile and outcomes were all collected. We have serum levels of zinc (zinc), copper (copper), selenium (Se) and manganese. We analyzed the severity in both groups. Results: Serum levels of copper, selenium and manganese in both groups were in the normal range and serum zinc levels were lower than normal. Based on these findings, serum levels of zinc, copper, selenium and manganese were not associated with disease severity (P <0.05). While we found that serum zinc levels were strongly associated with patient outcomes (P = 0.005). Our results showed that lower serum manganese levels were associated with age over 55 years (P = 0.006). Our results were not in favor of a clear significant relationship between serum trace element levels and disease severity.