Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

Abstract

Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. © 2009 American Chemical Society.