The study of anti-tumor effects of miR-375 loaded, folic acid-decorated dendrimer nanoparticles on oral squamous cancer (HN5) cells, in vitro

Abstract

Oral cancer is one of the most common cancers worldwide which causes more than 170000 deathes each year. Chemotherapy is one of the most essential existing therapies for this group of cancers but according to its systemic effects, subsequently serious complications can occur. Complexation of anticancer drugs to nanocarries like dendrimers, is a promising strategy that can eliminate the limitations of chemotherapy. On the other hand, discovery of interference RNAs has brought a paradigm shift in the field of cancer therapies development. Recent researchs indicates that, miRNA-375 is being downregulated in different cancers and can have anticancer effects. Combination of dendrimers and nucleic acids have a better efficacy for mammalian cells transfection. Folate receptors are endocytotic receptors with extreme tendency to folic acid molecules which are not usually expressed on healthy tissues but overexpressed in different cancers like oral cancer so they can be potentialy considered as a molecule targets for targeted therapies. Aim of this research is to study the anti-tumor effects of miR-375 loaded, folic acid-decorated dendrimer nanoparticles on oral squamous cancer (HN5) cells, in vitro.