Autoimmune hepatitis in Iranian children
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Abstract
Objective: To evaluate the clinical and para-clinical presentation, including autoantibody pattern, and response to treatment in Iranian children with autoimmune hepatitis (AIH). Methods: Data of 60 children presenting with AIH (56 girls) were analyzed retrospectively for clinical, serological and histological profile. Results: Clinical findings included jaundice (67%),hepatomegaly (50%) and ascites (30%). Forty children (38 girls) had type I AIH and 14 (12 girls) had type II AIH. Liver histology was comparable in the two groups and cirrhosis on initial biopsy was equally frequent in Types I and II AIH (63% vs 34%; p=ns). Conclusion: Our study describes the presentation and clinical course of Iranian children with AIH. Treatment with corticosteroids and/or azathioprine induces remission of autoimmune hepatitis clinically, biochemically as well as histologically. Copyright آ© 2007 by Indian Society of Gastroenterology.
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azathioprine, prednisolone, adolescent, article, ascites, autoimmune hepatitis, child, chronic liver disease, clinical feature, combination chemotherapy, controlled study, disease course, drug dose reduction, drug withdrawal, female, hepatomegaly, human, human tissue, hypergammaglobulinemia, Iran, jaundice, liver biopsy, liver cirrhosis, liver disease, liver failure, liver histology, magnetic resonance cholangiopancreatography, major clinical study, male, monotherapy, physical examination, recurrent disease, unspecified side effect, Adolescent, Adrenal Cortex Hormones, Azathioprine, Child, Child, Preschool, Female, Hepatitis, Autoimmune, Humans, Immunosuppressive Agents, Iran, Male, Retrospective Studies, Treatment Outcome