Determination of lisinopril using ?-cyclodextrin/graphene oxide-SO3H modified glassy carbon electrode

Abstract

An electrochemical method has been successfully demonstrated for sensitive determination of lisinopril with ?-cyclodextrin-graphene oxide-SO 3H composite modified glassy carbon electrode (?-CD/GO-SO 3H/GCE). Cyclic voltammetry, differential pulse voltammetry, and chronocoulometry were used to investigate the electrochemical behavior of lisinopril at ?-CD/GO-SO3H/GCE. The cyclic voltammetric results indicate that ?-CD/GO-SO3H/GCE can remarkably enhance electroactivity toward the oxidation of lisinopril in buffer solutions. The electrochemical behavior was further exploited as a sensitive detection scheme for the lisinopril determination by differential-pulse voltammetry. Under optimized conditions, the concentration range and detection limit were 0.21-190.4 and 0.11 ?M (S/N = 3), respectively. The method was successfully applied to assay the drug in human serum. é 2014 Springer Science+Business Media Dordrecht.