Evaluation of the effect of uterine flushing with hCG on biochemical and clinical pregnancy rate in the IUI cycle of couples with idiopathic infertility

Abstract

Although assisted reproduction technology (ART) success has been improved almost 30% of infertile couples worldwide are diagnosed with unexplained infertility. The study objective was to evaluate the pregnancy rates among primary unexplained infertile ladies who were affiliated with intra uterine hCG injection at the time of the hCG trigger in comparison with hCG trigger alone. Methods: A parallel randomized controlled trial was conducted involving 80 ladies with primary unexplained infertility at Al-Zahra Referral Academic Center. Participants were randomly allocated into two groups (40 subjects in each group). The intervention group received 1000 IU HCG diluted in 0.5 cc normal saline injected directly in uterus plus two intermuscular ampoules (5000 IU) of human chorionic gonadotropin (hCG) while the control group received only intermuscular hCG using intrauterine insemination (IUI) after 34-36 hours triggering to improve the pregnancy rates. Results: There was no significant relation between-groups regarding demographic and clinical characteristics such as endometrial thickness, and the number of follicles before intervention (p>0.05). The clinical pregnancy proportion was 32.8% (13/40) in hCG group versus 33.3% (13/40) in the intra uterine hCG group; (p=0.954). While chemical pregnancy rate was 32.8% (13/40) versus 33.3% (14/40). No significant associations were found for biochemical pregnancy and the number of gestational sacs (p=0.954).