Association between dietary patterns (Mediterranean, DASH, MIND) and dietary total antioxidant capacity with serum paraoxonase-1 enzyme level and disease risk in patients with coronary artery disease

Abstract

Findings: There was no significant relationship between DTAC, adherence to Mediterranean, DASH, and MIND dietary patterns, and PON-1 serum level between patients and the healthy group. There was no significant relationship between DTAC, adherence to Mediterranean, DASH, and MIND dietary patterns, and serum level of the PON-1 enzyme, risk of coronary artery disease, lipid profile, FBS, and anthropometric indices. A significant relationship was seen between waist circumference and DTAC (Beta= -0.22, 95 CI: (-0.51, -0.01). Serum level of PON-1 enzyme had no significant relationship with lipid profile, protein and energy intake, and anthropometric indices (weight, waist circumference, and body mass index). Serum level of PON-1 enzyme had an inverse and significant relationship with FBS and the amount of carbohydrate intake (Beta= -0.09, 95 CI: (-0.55, -0.10), p= 0.01), and a direct and significant relationship with the amount of total fat intake (Beta= 0.29, 95 CI: (0.06, 0.36), p= 0.01) and monounsaturated fatty acids (Beta= 0.43, 95 CI: (0.40, 3.26), p= 0.01). Conclusion: The dietary total antioxidant capacity and adherence to the Mediterranean, MIND, and DASH dietary patterns are not related to serum level of PON-1 enzyme and the risk of coronary artery disease. Keywords: Paraoxonase-1, Coronary Artery Disease, Anthropometry, Mediterranean Diet, Mediterranean-DASH Intervention for Neurodegenerative Delay, Dietary Approach to Stop Hypertension, Dietary Total Antioxidant Capacity