Study of the correlation between thermodynamic parameters and some physicochemical and pharmacokinetic parameters

Abstract

Objectives: This study was designed to investigate the correlation between thermodynamic parameters, ideal solubility and some pharmacokinetic parameters of the compounds. Methods: For thermodynamics analysis, 5 mg of pure drug was weighed in a aluminum pan. Thermodynamic parameters were used for determination of ideal solubility. Correlation between ideal solubility and physicochemical and pharmacokinetic parameters was investigated. Results: The results indicated that there is a linear correlation between ideal solubility and permeability with R=0.8. There are also meaningful correlation between ideal solubility and other physicochemical and pharmacokinetic parameters. Conclusion: This investigation revealed that the ideal solubility could be an appropriate parameter for prediction of drugs pharmacokinetics.