Synthesis and Evaluation of a Triblock Copolymer/ZnO Nanoparticles from Poly(?-caprolactone) and Poly(Acrylic Acid) as a Potential Drug Delivery Carrier
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Abstract
Through the present paper, a triblock copolymer containing pH-responsive (polyacrylic acid-b-polycaprolactone -b-polyacrylic acid) (PAA-b-PCL-b-PAA) was synthesized by using the ring-opening polymerization (ROP) of ?-caprolactone (?-CL) and the reversible addition fragmentation chain transfer (RAFT) polymerization of the acrylic acid methods, as the drug carrier. Blends of the nanocrystalline zinc oxide nanoparticles (n-ZnO) and triblock copolymer treated from the solution have been used to make the hybrid polymer-metal oxide for the preparation of the drug loaded nanocomposite. The drug-release behavior of the nanocomposite was studied by using the Doxorubicin as a model drug. In addition to the self-assembly and pH-responsive behavior of the triblock copolymers/ZnO was studied in solution by the Fluorescence Spectroscopy, Scanning Electron Microscopy(SEM), Transmission Electron Microscopy (TEM), DLS, HNMR and FT-IR spectroscopy. © Georg Thieme Verlag KGStuttgart · New York.
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acrylic acid, copolymer, doxorubicin, drug carrier, metal oxide, nanocomposite, polyacrylic acid, polyacrylic acid b polycaprolactone b polyacrylic acid, polycaprolactone, unclassified drug, zinc oxide nanoparticle, acrylic acid resin, antineoplastic antibiotic, carbopol 940, doxorubicin, drug carrier, metal nanoparticle, polycaprolactone, polyester, polymer, zinc oxide, Article, drug delivery system, drug release, evaluation study, fluorescence spectroscopy, gel permeation chromatography, infrared spectroscopy, nuclear magnetic resonance spectroscopy, pH, polymerization, proton nuclear magnetic resonance, reversible addition fragmentation chain transfer, ring opening, ring opening metathesis polymerization, scanning electron microscopy, synthesis, transmission electron microscopy, chemistry, electron microscopy, molecular weight, particle size, spectrophotometry, ultrastructure, Acrylic Resins, Antibiotics, Antineoplastic, Doxorubicin, Drug Carriers, Drug Liberation, Metal Nanoparticles, Microscopy, Electron, Molecular Weight, Particle Size, Polyesters, Polymers, Spectrophotometry, Zinc Oxide