The Effect of Pistacia atlantica Varmutica Mouthwash on Dental Plaque Bacteria and Subgingival Microorganisms: A Randomized and Controlled Triple-blind Study

Abstract

Dental plaque is a well-documented etiologic factor for periodontal diseases. While chlorhexidine (CHX) is the gold-standard agent for treating dental plaques, undesirable side effects are often found after continuous use of the mouthwash. Therefore, this single-center, randomized, triple-blinded and clinical trial was undertaken to evaluate the efficacy of Pistacia atlantica Var. mutica extract mouthwash on de novo dental plaque bacteria and subgingival microorganisms compared to CHX on a total of 28 patients. The mean aerobic plaque bacterial count of patients at baseline was 2.17--106. After 4 days of treatment, there were statistically significant decreases in the mean aerobic bacteria in the patients who received P. atlantica and/or CHX (7.25--104, p=0.006) and (9.91--103, p=0.002), respectively, compared to the patients who received the placebo (6.26--105). This study showed that P. atlantica mouthwash is effective against gingival microorganisms. Because of its reduced side effects, P. atlantica mouthwash may be a good alternative choice for patients. © Georg Thieme Verlag KG Stuttgart · New York.