School of Dentistry

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Tabriz Faculty of Dentistry is located in Tabriz, capital city of East Azarbayjan Province and is the only dental schoolwestern Iran. Tabriz Dental School was founded in 1986. The first students entered in 1987, graduating in 1993. In 1997 the school moved into a new and modern building, covering 22,000 square meters. The school expanded its educational programs in 2001 by offering its postgraduate specialty courses in three fields and at present it offers seven postgraduate specialty courses. Prospects for the Future We are determined, by asking for assistance from the Almighty, to promote the school's academic excellence, raise the standards of oral health in the community and join the circle of highly qualified dental schools in the country through optimizing instruction standards and innovative research programs. Mission Tabriz Faculty of Dentistry as the only dental school in the north-western Iran and as a part of a major university has combined and enjoyed the endeavors of competent and qualified academic staff with appropriate facilities and has committed itself to: Training highly qualified general practitioners and specialists; Updating the knowledge and skill of the graduates working in the north-western Iran;

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  • Item type: Item ,
    Evaluation of the biocompatibility and antibacterial effect of simvastatin nanoparticle coating on healing abutment of implants
    (Tabriz University of Medical Sciences, Faculty of Dentistry, 2025) Rasouli, Amin; Dental Prosthesis; Torab, Ali; Sharifi, Simin
    Introduction: Simvastatin is a lipid-lowering drug with other biological effects. Several studies have shown that simvastatin may have a protective effect on reducing complications and mortality from infections. One of the most devastating complications of orthopedic surgery is implant-associated infections (IAIs). Recently, newer strategies have been tried to reduce IAIs. Nanoparticles with antibacterial properties and coating on implant healing abutments can improve implant performance. This study investigated the cytotoxicity and antimicrobial effects of healing implant abutments coated with simvastatin nanoparticles (SIM-NPs). Materials and Methods: The MTT method was used to investigate cytotoxicity and the time-kill assay was used to evaluate the antibacterial effect of healing abutments coated with SIM-NPs. Results: The results showed that SIM-NPs coated on the healing implant abutment had no cytotoxic effect. The antibacterial effect evaluation test showed that SIM-NPs coated healing abutments had an antibacterial effect (p<0.05). Conclusion: Considering the favorable antibacterial effect and biocompatibility, SIM-NPs coated healing abutments can be considered for clinical application, although further animal and clinical studies should be conducted before that.
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    Comparison of the antibacterial efficacy of calcium hydroxide and Nanoparticle Calcium Hydroxide combined with chlorhexidine on Entrococcus faecalis_ an invitro study
    (Tabriz University of Medical Sciences ,faculty of Dentistry, 2025) Bagherpoor, Ehsan; Soroush Barhaghi, Mohammad Hosein; Abedi, Atefeh; Endodontics; Foroug Reyhani, Mohammad
    Introduction: Failure to completely disinfect the root canal system may lead to treatment failure and persistent apical periodontitis. This in vitro study investigated the time-dependent antibacterial efficacy of calcium hydroxide nanoparticles, calcium hydroxide, and their combination with chlorhexidine against Enterococcus faecalis. Materials and Methods: In this in vitro experimental study, 100 sterile paper cones No. 50 were immersed in Enterococcus faecalis microbial solution for 5 minutes. Then, the paper cones contaminated with microbes were placed in sterile containers and covered with 5 types of paste-like mixtures. The paste mixtures consisted of 5 groups (1- calcium hydroxide with distilled water, 2- calcium hydroxide with chlorhexidine, 3- calcium hydroxide nanoparticles with distilled water, and 4- calcium hydroxide nanoparticles with chlorhexidine, 5- normal saline (positive control)). At times 1, 2, 3, and 7 days, the paper cones were removed from the containers and placed individually in test tubes containing BHI broth microbial culture medium. The effects of microbial growth were evaluated by examining the formation of turbidity in the culture media. For analysis, SPSS24 software and independent t-tests, ANOVA analysis of variance were used to compare the turbidity of the samples (microbial growth) among the groups, and the repeated measures test was used to compare the turbidity during the studied times. The significance level in all tests was considered to be less than 5%. Results: All the studied groups showed antibacterial properties within one week and the amount of Enterococcus faecalis decreased significantly within one week. The addition of chlorhexidine significantly increased the antibacterial properties in both types of calcium hydroxide and calcium hydroxide nanoparticle combinations. Calcium hydroxide nanoparticle significantly increased the antibacterial properties. Calcium hydroxide nanoparticle and chlorhexidine had no significant effect on the antibacterial properties. Conclusion: Calcium hydroxide nanoparticle increases the disinfectant properties, but the effect of chlorhexidine is greater than that of nanoparticles.
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    Histopathological and Immunohistochemical Features of Oral Squamous Cell Carcinoma (OSCC) Based on PubMed database : A Scientometric Study
    (Tabriz University of Medical Sciences, School of dentistory, 2025) Bahloulifar, Zahra; Pathology, Oral; Fattahi, Shirin; Aliakbari khoei, Reza
    Introduction Information on the histopathology and immunohistochemistry of OSCC can contribute to better prognosis, diagnosis, and treatment of OSCC. This study examines the histopathology and immunohistochemistry of oral squamous cell carcinoma (OSCC) in publications indexed in the PubMed database from a scientometric perspective up to February 2024. Materials and Methods This scientometric study analyzed histopathology and immunohistochemistry studies on OSCC published in the PubMed database up to February 2024, using MeSH keywords. Studies that met exclusion criteria or had weak relevance to the study objectives were removed. Reference management was conducted using EndNote Basic, where duplicate references were identified and removed. All statistical analyses and chart visualizations were performed using the R software and the Bibliometrix package. Additionally, a bibliometric map was generated for further interpretation. Statistical analyses were conducted using open-source R software to achieve study objectives such as identifying top researchers, leading institutions, trending topics, and publication trends over the years. Results A total of 3,128 articles published between 1974 and 2023 were identified, appearing in 551 journals. These documents contained a total of 7,115 keywords. A total of 22,125 authors contributed to these publications. In total, 17 documents were single-author publications, while the rest were collaborative works. Based on the findings, an average of 7.07 authors contributed per document. The international collaboration rate among authors was found to be 69.9%. Conclusion The results indicate that more research, particularly animal studies, is needed on topics such as neoplasm invasiveness, disease progression, cell proliferation, gene expression regulation, and tumor cell lines. Keywords: Oral Squamous Cell Carcinoma, Immunohistochemistry (IHC), Histopathology, Scientometrics
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    The effect of adding metronidazole on solubility, setting time and the antimicrobial properties of glass ionomer cement
    (Tabriz University of Medical Sciences ,faculty of Dentistry, 2025) Azizi, Ali; Dental Prosthesis; Mousavi, Amin
    A pathogen-free environment is essential for the high success of any restorative or endodontic procedure. Glass ionomer cement has the advantage that its biological and physical properties can be modified simply by changing the powder to liquid ratio or by changing the chemical formulation. The present study was conducted to investigate the effect of adding metronidazole on the solubility, setting time and antibacterial properties of glass ionomer cement. Materials and Methods In this laboratory study, 40 discs of cement and metronidazole mixture and 40 discs of cement without metronidazole (control) were prepared. Light cure glass ionomer cement powder (GC Fuji IX, GC Corporation) was physically mixed with metronidazole powder at a weight percentage of 10 to 90. For solubility testing, the ISO 4049 solubility test and the setting time evaluation were measured according to ISO6873 standards using a Vicat apparatus. In order to investigate the antibacterial property, the disk diffusion method and the diameter of the growth inhibition zone were used. SPSS24 software and Mann-Whitney test were used to analyze the data. A probability value of less than 5 percent was considered as a significant level. Results The solubility rate in the metronidazole-containing cement group (23.98±4.05) was not significantly different from the control group (20.89±3.99). The setting time in the metronidazole-containing cement group (5.96±0.49) was significantly greater than the control group (5.21±0.32). The diameter of the growth inhibition zone in the metronidazole-containing cement group (19.99±0.54 mm) was significantly greater than the control group (7.82±0.50 mm). Conclusion It seems that the combination of metronidazole with glass ionomer cement can be a suitable restorative material.
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    Comparison of the success rate of two anesthetic techniques using lidocain 2% in mandibular secondary premolars with symptomatic irreversible pulpitis: Randomized controlled clinical trial
    (Tabriz University of Medical Sciences ,faculty of Dentistry, 2024) Fereydoonzadeh, Maryam; Forogh Reyhani, Mohammad; Endodontics; Ghasemi, Negin
    Aim: The purpose of this study was to compare the effectiveness of inferior alveolar nerve block (IANB) and the combination of buccal infiltrations and periodontal ligament injection as a primary injection for providing anaesthesia to mandibular premolars with symptomatic irreversible pulpitis. Materials and Methods: This randomised clinical trial included eighty patients diagnosed with symptomatic irreversible pulpitis in mandibular second premolars. Patients were randomly divided into two treatment groups (N = 40) according to the administered technique: Group 1 (IANB): standard inferior alveolar nerve block (IANB) injection by 1.8 mL of lidocaine 2%; Group 2 (BI + PDL): buccal infiltration (0.9 ml of carpool) followed by periodontal ligament injection (0.9 ml of carpool) after 5 minutes. Patients rated pain intensity using a visual rating scale (VAS) during access preparation and entering the pulp chamber. Statistical analysis was performed using an independent T-test and Mann-Whitney U test. The level of statistical significance was set at 0.05. Results: The patients receiving IANB injections had a success rate of 53.85 %, whereas buccal infiltration followed by intraligamentary injection was successful in 77.78 % of cases (P-value = 0.01). No significant difference was between the two injections during access preparation and entering the pulp chamber (P-value > 0.05). However, there was a statistically higher pain during canal instrumentation when the IANB technique was used (P-value = 0.032). Conclusion: Considering the limitations of this study, we concluded that buccal infiltration followed by intraligamentary injection could be employed to achieve successful anaesthesia during the endodontic management of mandibular premolars with irreversible pulpitis.
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    Examining the level of satisfaction of clinic course students with virtual education
    (Tabriz University of Medical Sciences ,faculty of Dentistry, 2025) Pasha Abgarmi, Shima; Negahdari, Ramin; Surgery, Oral; Pourlack, Tannaz; Mortazavi, Ali
    Objective: In line with the emergence of information and communication technology, the most important challenge of education in the 21st century, virtual education has transformed the traditional ways of searching for information in today's research and technological world and despite challenges such as the increasing demand for higher education and lack of Adequacy of the budget, lack of full-time academic staff and the need to remove geographical restrictions have been given serious attention. In virtual education, quality is essential to prevent the wastage of human capital, and material and financial industries. This study was conducted to investigate the satisfaction level of Tabriz Dental Faculty clinic students with virtual education. Materials and methods: The current study is analytical-cross-sectional. The students of the clinical course of Tabriz Faculty of Dentistry with a history of passing at least one of the theoretical courses of the clinic course were included in the study. This study was conducted by self-report questionnaire. Frequency and percentage were used to describe qualitative data, and mean and standard deviation were used for quantitative data. Descriptive statistics including mean, median, coefficient of variation, standard deviation, and percentiles were used to describe dental students' satisfaction scores from virtual education based on the year of entry. Pearson's correlation coefficient was used to determine the correlation between the total scores of the questionnaire and the number of related years of education. Statistical calculations were done using SPSS version 26 software. Results: The average satisfaction score of dental students in the clinic course with virtual education was 47.05out of 84, indicating relative satisfaction. Scores ranged from 27 to 78, and the data distribution was reported to be normal. No statistically significant differences were observed between satisfaction and demographic variables including age, gender, year of university entry, and academic semester. Also, satisfaction scores did not differ significantly between different university entrances and academic semesters. Conclusion: The results of this study indicate that virtual education, as a complementary method in clinical dental education, has a relative level of satisfaction among students..
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    Synthesis of PH sensitive polymer and evaluation of its efficiency in controlled loading and release of fluoride
    (Tabriz university of medical sciences, faculty of dentistry) Asadi, Meysam; Sarvari, Rana; Orthodontics; Sadrhaghighi, Amirhoman
    Introduction: Studies have shown that orthodontic treatments increase the incidence of caries lesions. Today, various studies have suggested adding fluoride to various dental materials such as dental composites, glass ionomer, orthodontic adhesives, or fluoride coating on the surface of orthodontic appliances. One of the best ways to improve this situation is the slow release of fluoride in the oral environment. The purpose of this study is to prepare poly(2-dimethylaminoethyl) methacrylate polymer and to evaluate the ability of carrying and releasing fluoride by this compound. Materials and methods: Poly (2-dimethylaminoethyl) methacrylate polymer was prepared by atom transfer radical polymerization (ATRP). FT-IR, NMR and SEM tests were used to evaluate the chemical properties and surface properties and morphology of the resulting compound. AT-FTIR in the range of cm-¹ 400-4000 and scanning speed cm-¹ 16 was used to investigate functional groups. MMT was used to investigate toxicity. For the initial load, from poly(2-dimethylaminoethyl) methacrylate samples, 0.02 grams of polymer was added to 10 cc of 0.2% fluoride mouthwash and placed in a shaking incubator at 37°C for 10 minutes. The polymer loaded in the mouthwash was separated using a centrifuge. The loaded polymer was added to artificial saliva (pH=7). The amount of fluoride released was evaluated every day for 10 days. After the initial evaluation, the polymer was recharged with the previous method and separated by centrifugation, and then the amount of fluoride release was evaluated in three cycles and pH 4 and 7 in different time intervals. Results: The release rate of fluoride at pH 4 was higher than at pH 7. that this difference is significant in the first and second hour. (p value < 0.05)) The maximum release of fluoride in both pH is in the first hour Also, the ability of the polymer to release fluoride does not decrease or increase significantly after each charge in different cycles This polymer has the ability to release fluoride for at least ten days with a single charge, and the process of fluoride release is decreasing during ten days. Conclusion: The release rate of fluoride from the polymer synthesized at pH 4 was higher than at pH 7; With a single charge, it can release fluoride for at least ten days. Also, the ability to release fluoride does not decrease with recharging.
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    Evaluating fractal analysis as a predictor of dental implant osseointegration
    (Tabriz University of Medical Sciences, School of Dentistry, 2025) Mohammadi, Nima; Bayat, Narges; Radiography, Dental; Esmaeily Gavgani, Farzad
    Background: The success of dental implants is closely linked to the quality and structural complexity of the surrounding trabecular bone, which can be quantitatively assessed using fractal analysis (FA). This study aimed to evaluate FA values of trabecular bone in the mesial, distal, and apical regions before, during, and three months after implant placement, while also examining the influence of demographic factors such as age and gender on bone quality and implant outcomes. Materials and Methods: FA was calculated from orthopantomograms (OPG) for three regions of interest (ROIs) adjacent to the implant, named mesial, distal, and apical, before implant placement and three months post-implantation. Statistical analyses, including paired t-tests and effect size calculations (Cohen’s d), were performed to compare FA values across time points and demographic groups (age: 18–45 years vs. 45–65 years; gender: male vs. female). Results: A total of 150 patients that received dental implants in premolar/molar areas of mandible were included in this study. Significant gender-based differences were observed, with men consistently exhibiting higher FA values across all regions and time points (P<0.001, Cohen’s d=0.91–2.28). Younger individuals (18–45 years) demonstrated significantly higher FA values compared to middle-aged individuals (45–65 years), particularly in the apical region (P<0.001, d=2.57). Temporal analysis revealed stable FA values in the mesial and distal regions, with a slight but significant reduction in the total FA post-implantation (P=0.031, d=0.178). Conclusion: This study highlights the significant influence of age and gender on trabecular bone quality, as reflected by FA values. While FA analysis provides valuable insights into peri-implant bone remodeling, it may not be sufficient alone to determine initial implant stability. The findings suggest that FA analysis, when combined with other diagnostic tools, can enhance the assessment of bone quality and contribute to personalized implant treatment strategies. Further research with larger sample sizes and standardized protocols is recommended to validate these findings and improve clinical applications.
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    Determination of the success rate of Fissure sealant therapy and its related factors in children referred to Tabriz University of Medical Sciences Faculty of Dentistry
    (Tabriz University of Medical Sciences, School of dentistry, 2025) Rostami, Majid; Pediatric dentistry; Mahbobi, Zeinab; Erfanparast, Leila
    Introduction Several methods have been proposed for preventing caries in children and adolescents, one of which is the application of sealants to the pits and fissures on the occlusal surfaces of permanent molar teeth. Several factors influence the success rate of sealant treatment. Most studies have focused on clinical factors affecting the success of sealant treatment, often aiming to compare and confirm the advantages of various materials used as sealants, as well as the conditions for preparing the teeth. However, there have been few studies on the role of factors that may indirectly affect the outcomes of sealant treatments. The present study aimed to determine the success rate of sealant treatment and its related factors in children referred to the Faculty of Dentistry, Tabriz University of Medical Sciences. Materials and Methods: The present study was a cross-sectional analytical study targeting children who had received pit and fissure sealant treatment. Children who had received sealant treatment at Tabriz Dental School were invited to participate in the study. By reviewing the archive file of patients referred to the faculty, 65 children aged 7 to 13 years were identified who had been referred to the pediatric department of Tabriz Dental School for sealant treatment within the past one to two years. All of them were invited to participate in the study, and ultimately, 57 of them agreed to take part in the study. In order to measure the outcome variable, the success rate of sealant treatment was examined and evaluated using a dental probe and oral mirror on the dental unit under sufficient light. The treatment's success in this study was defined as the complete presence of sealant material with no underlying secondary decay; failure was defined as the presence of secondary decay under sealant or either a complete or incomplete absence of sealant material. To collect data for independent variables including demographic factors (age and gender) and socio-economic factors (parents' job and place of residence), a general data collection questionnaire was used, for the variables of parents' education level, child nutrition, frequency of brushing and use of fluoride toothpaste, the WHO questionnaire was used. and to record the history of previous caries, previous records of patients in the pediatric ward of the faculty was used. To investigate the relationship between independent variables and the success rate of sealant treatment as an outcome variable, first, univariate analysis was performed using logistic regression, and the relationship of each independent variable with the outcome variable was analyzed separately. Then, considering confounding variables and for multiple regression analysis, variables with a P-value < 0.2 were candidates for multiple analysis to evaluate their simultaneous effect on the outcome variable. In the present study, a significance level of 0.05 was considered, and the analyses were performed using SPSS version 26 software. Results: The results of this study indicated that sealant treatment was successful in 56% of the participants. Multiple logistic regression analysis revealed that three factors—living district, frequency of tooth brushing, and history of tooth decay in children—were significantly associated with the success of sealant treatment. The success rate was higher among children living in affluent areas, those who brushed their teeth more frequently, and those with a history of fewer cavities. Conclusion: In this study, we examined how the number of previous dental caries, the living district, and the frequency of tooth brushing relate to the success of sealant treatment. The findings suggest that careful case selection for sealant treatment can significantly impact treatment outcomes. Specifically, for children from low socioeconomic backgrounds, those with a high number of decayed teeth, and those with poor oral hygiene, sealant treatment should be approached with caution, and follow-up should occur at shorter intervals.
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    Investigation of the effect of zirconia acid etching time on the shear bond strength between porcelain veneer and a type of zirconia block
    (Tabriz University of Medical Sciences, Faculty of Dentistry, 2025) Mortazavi, Seyyed Mustafa; Barzegar, Ali; Dental Prosthesis; Motiei, Mehrnaz
    In this study, we used 60 zirconia block samples whose standards were checked and then their surface was prepared. In fact, the standards of the zirconia sample, including the correct size, the absence of bubbles and nodules, the correct thickness and diameter, were controlled and followed. The acid solution of zircos-e etching solution was considered in three etching times of half, one and two hours and was compared with the control group (without etching). After surface preparation, porcelain was baked on the samples and its thickness was measured by micrometer. To measure the bond strength of each sample, the area between porcelain and zirconia was subjected to shear stress using a universal test machine at a speed of 1 mm/min until breaking. The maximum breaking force was recorded in Mpa. In fact, the criterion for examining fractures was the blind color difference between zirconia and porcelain veneers. At the end, the best etching time to prepare the surface of the zirconia block was selected and introduced based on the bond strength. The test results were reported as mean and standard deviation. The median was not used to establish normality. Graphs were used to show the value of resistance among groups. First, the normality of the data was tested with the Kolmogorov Smirnov test. To compare the average resistance between the two groups, T-test was used to establish normality, and Mann-Whitney's test was not used. Analysis of variance was used to compare the average resistance among the four groups. Due to the significance of the analysis of variance, the amount of resistances was compared in pairs among the groups. Bonferroni's test was used to compare two groups. Due to the establishment of normality, the Kruskal-Wallis test and its follow-up tests were not used. Two-way analysis of variance was also used to evaluate the interaction effect of time and band type. A probability value of less than 0.05 was considered as a significant level. SPSS version 19 software was used for data analysis.