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There is a positive association between vitamin B12 deficiency and serum total cholesterol in Iranian type 2 diabetic patients on Metformin [Il existe une association positive entre la carence en vitamine B12 et le cholestérol total plasmatique des patients iraniens diabétiques de type 2 sous Metformine]
(2018) Niafar, M; Samadi, G; Aghamohammadzadeh, N; Najafipour, F; Nikniaz, Z
Introduction Considering the low level of vitamin B12 in diabetic patients on Metformin and also the importance of this vitamin in lipid metabolism, the aim of the present study was assessing the possible relationship between vitamin B12 deficiency, lipid profile and atherogenic indices in Iranian diabetic patients. Method In the present cross-sectional study, a sample of 200 patients with type 2 diabetes was selected. Serum level of lipid profile was measured using enzymatic colorimetric method. LDL-C was calculated by Friedewald equation and atherogenic indices including total cholesterol to HDL-C and Log Triglyceride to HDL-C ratio were calculated. Serum level of vitamin B12 was measured photometrically using commercial kit. Results The prevalence of vitamin B12 deficiency was about 14%. There was a significant difference between normal participants and vitamin B12 deficient subjects in the case of total cholesterol (P = 0.04). The results of the regression analysis showed that in adjusted model, there was significant association between total cholesterol and vitamin B12 deficiency (OR: 16.46 [95% CI: 0.27, 33.19], P = 0.04). Conclusion The results of the present study showed the relatively high prevalence of the vitamin B12 deficiency in type 2 diabetic patients who were on Metformin. Moreover, there was a significant association between vitamin B12 deficiency and total cholesterol level in diabetic patients. Further studies with larger sample size and considering dietary information and duration of Metformin consumption are needed to confirm these preliminary results.
Synthesis of graphene oxide supported copper-cobalt ferrite material functionalized by arginine amino acid as a new high-performance catalyst
(2018) Ghadari, R; Namazi, H; Aghazadeh, M
A novel Cu0.5Co0.5Fe2O4@Arg-GO catalytic system was successfully prepared by immobilization of copper substituted cobalt ferrite nanoparticles on arginine-grafted graphene oxide nanosheets, in which ferrite moiety acts as an oxidation catalyst and arginine has the role of base catalyst. Also, arginine amino acid was used to modify the surface of graphene oxide nanosheets which the prepared support can improve dispersion and uniform loading of nanoparticles. The prepared nanocomposite was characterized by flame atomic absorption spectroscopy (FAAS), inductively coupled plasma optical emission spectrometer (ICP-OES), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-vis), Raman spectroscopy, thermogravimetric analysis (TGA), x-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. The prepared Cu0.5Co0.5Fe2O4@Arg-GO nanocomposite was used as an efficient catalyst for one-pot tandem oxidative synthesis of 2-phenylbenzimidazole derivatives in good yields.
Comparing Longterm infusion of Dexmedetomidin versus midazolam in mechanically ventilated patients admitted to intensive care unit
(Tabriz University of Medical Sciences, Faculty of Medicine, 2018) Pilevar, Nina; Sanay, Servin; Kamran, Shadvar; Mahmood pour, Ata; Hamishe Kar, Hadi
There are many controversies about the effect of dexmeditoimidine in comparison with other sedative drugs and insufficient evidence for the duration of treatment. Therefore, we decided to investigate the effect of long-term exposure to dimethomidine infusion with midazolam infusion in patients underwent mechanical ventilation in ICU. Materials and Methods: This study was a double-blind, randomized trial. All patients over 18 years of age requiring mechanical ventilation for more than 24 hours in ICU were randomly divided into two groups (dexmodetomidine group (0.4-4.8 μg/kg/h) and midazolam Dose of 0.4 mg/kg/h). In all patients, a washout period was performed from 7-9 a.m. to assess the patient's state of consciousness. Demographic data including age, sex, and patients' records were recorded. Possible complications including hypotension, bradycardia and RASS were evaluated every 4 hours. Finally, all the data entered the SPSS v19 statistical analysis program and we analyzed the data. Results: This study was performed on 101 patients hospitalized in ICU and 50 patients received midazolam and 51 patients with doxedetomidine. The mean age of patients in dexmeditomidine group was 59.11 ± 12.33 years and in midazolam group was 59.12 ± 13.48 years. The dominant gender in both groups was also men. It was also observed that after Washout, in the doxedetomidine group, 84.3% and midazolam group received 64% consciousness (P = 0.020). Also, more patients in the group receiving midazolam received the second drug for cirrhosis (P = 0.004). Also, the duration of desensitization in the dexmeditomidine group was 82.85 hours and in the midazolam group was 67.08 ± 11.88 (P = 0.000). Complications were also observed in 17.6% of the patients receiving dextromyidine and 11.7% of them had pneumonia. In the midazolam group, 34% had delirium and 20% had pneumonia. Also, 11.8% of patients with doxedetomidine and 18% of midazolam patients died during hospitalization (P = 0.378).
Comparing the effects of high dose and low dose corticosteroids in breast granulomatous mastitis and fistulisation, A Cross Sectional
(Tabriz University of Medical Sciences, Faculty of Medicine, 2018) Dadashzadeh, Maryam; Montazer, Majid
Granulomatous mastitis is a rare secondary complication of a great variety of other Granulomatous disease with similar clinical symptoms. This might lead to a misdiagnosis and delayed treatment plan costing the patient and the therapeutic system. Method and Materials: This research is cross-sectional study designed to determine the effect of high and low dose corticosteroid therapy on patients returned with pain, swelling or mass, to the Tabriz University of Medical Science clinic and Imam Reza hospital in Tabriz, since April 2016 to April 2018. Results: The results of this study were based on data of 30 extracted cases with diagnosis of Granulomatous mastitis, 15 patients teated with low dose corticosteroid and 15 patients teated with high dose corticosteroid. The case study contains checklists and information from thirty patients that were chosen according to the input/output criteria. All of the patient were female with the age range of 21 to 47 and the mean age of 32.8±1.36. Majority of the patients complained about pain and feeling mass, discharge, inflation or any combination of them. None of the cases have had any of the systemic diseases or any specific Granulomatous or breast related issues in record. None of them were a contraceptive agents user. All the cases were within their fertile age with on average two children. Although all the serologic and bacterial tests returned negative. 2 cases had to be subjected to abscess drainage due to the nonstop discharge and multiple abscesses. All the patients prescribed 2 months of steroid treatment. They were put into two groups for high and low dose treatment plans and assigned a followup for the feedback. The plan was extended up to 1 year for the cases who were not cured by the original period and all remediated. All the cases were studied through sonography over time and the curing sings were recorded. There was a reasonable correlation between high dose of corticosteroid therapy and full treatment of the patients.( p-value < 0.01)
Probiotics and metabolic outcomes of gestational diabetes: A review article
(2018) Hajifaraji, M; Dolatkhah, N
Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy. Compared with individuals without diabetes, women with GDM, in absence of intervention, are at higher risk of adverse maternal and fetal outcomes. The recent and unexpected increase in the prevalence of GDM and the average results of dietary interventions could partly be due to inattention or failure in modifying the new composition and inappropriate intestinal micro flora which occurs often in the second half of pregnancy particularly when accompanied by obesity. In the spectrum of lifestyle-related factors, probiotics are proposed as part of a balanced diet, affordable, practical and potentially effective approach to this health problem. The purpose of this narrative review paper was to review previous studies according to the importance of probiotics and their role in prevention and treatment of GDM. Electronic search was done in databases, including Scopus, Science direct, PubMed, Cochrane central, Google Scholar, ISC, Magiran, IranMedex, SID, and MedLib. Evidence suggest that manipulation of microbiota in gut during pregnancy by selected probiotics in women at risk of or affected by GDM, can probably be of great benefit in improving the metabolic profile of mother and pregnancy results. é 2018, Mazandaran University of Medical Sciences. All rights reserved.
Development of salt and pH-induced solidified floating organic droplets homogeneous liquid-liquid microextraction for extraction of ten pyrethroid insecticides in fresh fruits and fruit juices followed by gas chromatography-mass spectrometry
(2018) Torbati, M; Farajzadeh, MA; Torbati, M; Nabil, AAA; Mohebbi, A; Afshar Mogaddam, MR
A new microextraction method named salt and pH-induced homogeneous liquid-liquid microextraction has been developed in a home-made extraction device for the extraction and preconcentration of some pyrethroid insecticides from different fruit juice samples prior to gas chromatography-mass spectrometry. In the present work, an extraction device made from two parallel glass tubes with different lengths and diameters was used in the microextraction procedure. In this method, a homogeneous solution of a sample solution and an extraction solvent (pivalic acid) was broken by performing an acid-base reaction and the extraction solvent was produced in whole of the solution. The produced droplets of the extraction solvent went up through the solution and solidified using an ice-bath. They were collected without centrifugation step. Under the optimum conditions, limits of detection and quantification were obtained in the ranges of 0.006-0.038, and 0.023-0.134 ng mL-1, respectively. The enrichment factors and extraction recoveries of the selected analytes ranged from 365-460 to 73-92%, respectively. The relative standard deviations were lower than 9% for intra- (n = 6) and inter-day (n = 4) precisions at a concentration of 1 ng mL-1 of each analyte. Finally, some fruit juice samples were effectively analyzed by the proposed method. é 2017
Evaluation impact of point of use (POU) household water treatment devices (HWTDs) application on tap water quality and determine the removal efficiency of THMs and HAAs
(2018) Dehghanzadeh, R; Talebzadeh, N; Taghipour, H; Aslani, H
Application of household water treatment devices (HWTDs) is increasing due to the lack of confidence on supplying safe water by municipal drinking water distribution systems. The main objective of this study was to determine performance of HWTDs in the removal of trihalomethanes (THMs) and haloacetic acids (HAAs), color, turbidity, lead and copper from household tap water. The amount of THMs and HAAs in the inlet water samples was obtained more than the drinking water maximum recommended levels. No significant correlation was obtained between removal efficiency of disinfection by products (DBPs), and color and turbidity. Maximum concentrations of THMs and HAAs at the inlet water samples were 156.35 and 124.20 آµg l-1, respectively. Highest concentration of THMs and HAAs at the outlet water samples were 47.11 and 45.40 آµg/l, respectively. HWTDs showed better performance in reducing HAAs than THMs. The devices showed maximum removal rate for dibro-mochloromethane (DBCM) and dichloroacetic acid (DCAA) with values of 85 and 74%, respectively. The results showed that HWTDs might not completely remove heavy metals and DBPs, however, these devices can help maintain the health of consumers with reducing the level of harmful compounds in municipal drinking water. é 2018 Desalination Publications. All rights reserved.
Investigation the prevalence of vitamin D3 deficiency and evaluation of its relationship with glycemic control in diabetics under CABG operation in the ICU of Shahid Madani hospital in 2017.
(Tabriz University of Medical Sciences, Faculty of Pharmacy, 2018) Nazeri, Parisa; Entezari Maleki, Taher; Eghbal, Mohammad ali; Nasiri, Babak
Background It is now generally accepted that vitamin D3 deficiency is most common worldwide nutrient deficiency. Today according to importance of Vitamin D3’s roles in the body functions and probability of level of vitamin D3’s relationship with chronic disease amongst type 2 of (Diabetes mellitus) DM, vitamin D3 is much considered. Therefore we decided to study the prevalence of vitamin D3’s deficiency in diabetic patients under CABG operation and determine evaluation of it’s relationship with glycemic control after operation. Objectives Our objectives was investigation the prevalence of vitamin D3 deficiency and evaluation of it’s relationship with glycemic control (acute hyperglycemia) in diabetic patients under CABG operation in the ICU of Shahid Madani hospital in 2017. Materials and Methods A cross sectional study has been carried out on 115 diabetic patients undergoing CABG in ICU of Tabriz Shahid Madani hospital in 8 months. The demography data, history of basis disease, drug history, levels of vitamin D3 and glucose levels of patients was obtained in the questionnaire. Findings In the current work 348 patients has been underwent CABG operation which 115 of those were diagnosed diabetic patients. The results of prevalence of vitamin D3 deficiency show a 73,2% deficiency in the diabetic patients. There was a significant difference in average of blood glucose levels and vitamin D3 (p=0.0004). Conclusions Patient’s sufficient level of vitamin D3 before operation causes better glycemic control in diabetic patients undergoing the CABG operation after that and for achievement to this results prescribing vitamin D3 before operation should put in the executive order of the hospital.
Barriers to Remarriage Among Older People: Viewpoints of Widows and Widowers
(2018) Osmani, N; Matlabi, H; Rezaei, M
We conducted this research based on a qualitative approach to describe the opinions of older widows and widowers on remarriage obstacles. Based on purposive sampling and inclusion criteria, we chose 48 participants on maximum diversity of sex, age, education, employment, and socioeconomic status. Two thirds of the participants were female, 40% had spent more than 10آ years widowed, and 65% were living with their children. We collected data individually through semistructured, face-to-face interviews. Based on conventional content analyses, 2 independent researchers implemented data analysis manually. Barriers to remarriage were finally categorized into 4 main themes: personal, normative, interactive, and financial factors. Results of this study showed that older people are more concerned about public opinions and social norms surrounding remarriage. As long as these thoughts and norms are not changed, the concept of remarriage among widows and widowers remains a vital taboo and concern. آ© 2017 Taylor & Francis Group, LLC.
Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol.
(2018) Asghari, F; Haghnavaz, N; Shanehbandi, D; Khaze, V; Baradaran, B; Kazemi, T
MicroRNAs (miRNAs) are small non-coding RNAs which have been considered as major players in the process of carcinogenesis and drug responsiveness of breast cancer.In this study, we aimed to investigate the expression pattern of let-7a and miR-205 tumorsuppressor miRNAs in breast cancer cell lines under treatment with paclitaxel.The half maximal inhibitory concentration (IC50) of paclitaxel was determined for 4 breast cancer cell lines, including MCF-7, MDA-MB-231, SKBR-3, and BT-474 by an MTT assay. The expression level of let-7a and miR-205, and their targets, K-RAS and HER3, was determined before and after treatment with paclitaxel, using quantitative reverse transcriptase real-time polymerase chain reaction (qRT-PCR).After treatment, the expression level of both let-7a and miR-205 was significantly increased in HER2- overexpressing cell line BT-474 (26.4- and 7.2-fold, respectively). In contrast, the HER2-negative cell lines MCF-7 and MDA-MB-231 showed a significantly decreased expression of both let-7a (30.3- and 13.5-fold, respectively) and miR-205 (20- and 18.1-fold, respectively). Controversially, SKBR-3 revealed a significantly decreased expression of both let-7a (1.3-fold) and miR-205 (1.3-fold). The expression level of K-RAS as a target of let-7a decreased in all cell lines significantly, but the pattern of alteration in the expression level of HER3 as a target of miR-205 in all cell lines was the reverse of the pattern of alteration in the expression level of miR-205.Our results confirmed a better response of HER2-overexpressing breast cancer to paclitaxel at the miRNA level. One putative reason could be the upregulation of tumor-suppressor miRNAs after treatment with paclitaxel. On the other hand, HER2-negative breast cancer cell lines showed a significantly decreased expression of tumor-suppressor miRNAs, a putative mechanism of resisting the therapy.
A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6?mercaptopurine
(2018) Ghorbani, M; Hamishehkar, H
The clinical applications of anticancer drugs are restricted due to the incomplete delivery to the cancerous tissue and the numerous drug resistance mechanisms involved in malignant cells. In this regard, stimuli-responsive nanomaterials offer a promising prospect to deal with these concerns. In the present study, ternary responsive hybrid gold/nanogels (Au/NGs) were synthesized as a new nanoplatform to simultaneously carry two anticancer drugs, i.e., doxorubicin (DOX) and 6-mercaptopurine (MP). For this purpose, these drugs were successfully loaded (the loading capacity of 23% and 11%, respectively) into the hybrid Au/NGs by electrostatic interaction (DOX) and Au-S bonds (MP). The triggered drug release ability of hybrid Au/NGs was assessed by comparing the environments of simulated physiological and tumor tissue. The incorporation of disulfide bond linkers, pH sensitive, and thermosensitive polymeric segments endowed the NGs with an excellent property in reducing acidic and hyperthermia environments, which greatly facilitates drug release in tumor cells. Intracellular tracking of DOX@MP-Au/NGs confirmed efficient accumulation and cellular uptake of developed NGs and the cytotoxicity studies showed a pronounced tumor inhibition compared with free DOX@MP. It was concluded that the new ternary-responsive NGs have great potential for co-delivery of DOX and MP and can be used in efficient cancer therapy. é 2018
Bulky organosilicon compounds based on sulfanyltetrazoles: their synthesis and in vitro antibacterial evaluation
(2018) Baghershiroudi, M; Safa, KD; Adibkia, K; Lotfipour, F
The study introduces different organosilicon derivatives incorporating sulfanyltetrazole ring for biological applications. Initially, the sulfanyltetrazole derivatives and halo-analogues (Br, I) were synthesized. Later, selective reaction of tris(trimethylsilyl)methyllithium (TsiLi) in the presence (-46 and 0 degrees C) and absence (room temperature) of CS2 with halo-sulfanyltetrazole derivatives yielded new multifunctional sulfanyltetrazole regioisomers with SH, C = S, ethynylthio and SiMe3 groups, respectively. All the synthesized compounds were characterized by IR, H-1-NMR, C-13-NMR spectra and elemental analysis data. The compounds were screened for their antibacterial activities against clinically important gram-positive and gram-negative bacteria using the spectrophotometric microdilution method. The preliminary screening indicated that the organosilicon derivatives incorporating SH and C = S (mercapto-silyl-thiones) and silyl-thioalkynes have antibacterial activities, whereas no antibacterial activity was observed on compounds containing (Me3Si)(3)C groups. Of the synthesized compounds, compound 5d showed the best activity against all the tested organisms (3.91-31.25 mu g/mL).
Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats.
(2018) Shokoohi, M; Shoorei, H; Soltani, M; Abtahi-Eivari, SH; Salimnejad, R; Moghimian, M
This study was designed to determine the effects of daily oral administration (250آ mg/kg) of the hydroalcoholic extract of Fumaria parviflora (FP) for 14آ days on the sperm parameters, oxidative stress parameters, serum testosterone levels, expression of Bax and Bcl-2 genes, and apoptosis index of germ cells after testicular torsion-detorsion (ischaemia-reperfusion, IR) injury model in rats. Twenty-eight adult male Wistar rats were divided randomly into four groups of seven each: sham operation, torsion-detorsion (TD), TD plus the hydroalcoholic extract FP (TDFP) and only FP without TD application (FP). Testicular torsion was created by rotating the left testis 720آ° in a counterclockwise direction; then, after 4آ hr, detorsion was performed. The Johnson's score, mean seminiferous tubule diameter (MSTD) and height (thickness) of seminiferous tubule epithelium (HST) were significantly increased in TDFP and FP groups as compared to TD group. The gene expression of Bcl-2, level of serum testosterone hormone and antioxidant parameters-GPx and SOD-were significantly higher in TDFP and FP groups than TD group. The index of apoptosis, the gene expression of Bax and the level of MDA were significantly higher in TD group than TDFP and FP groups. Therefore, F.آ parviflora could decrease oxidative stress induced by testicular torsion-detorsion.
The impact of reminiscence on the quality of life among institutionalized older people in Ilam, Iran
(Tabriz University of Medical Sciences, School of Health, 2018) Seydi, Adnan; Musavi, Saeed; Matlabi, Hossein
Background: Expression of memory may increase the attention of the elderly to themselves and help them cope with the crises and the process of aging. The purpose of present research was to determine the impact of reminiscence on the quality of life among institutionalized older people in Ilam, Iran. The method of study: The research was carried out based on quasi- experimental approch (pre and post-test). Statistical population was consisteds all the elderly people were institutionalized in nursing homes of Ilam and Ivan. Based on inclusion and excluiosn criteria, 60 participants were chosen. Before intervention, the status of quality of life was evaluated by using SF-36. The intervention was conducted in 8 sessions. The participants expressed their memories such as bitter and sweet memories in different periods of life, and finally the quality of life of the participants was reevaluated according to the same questionnaire. T- Paired test was used to compare the data. Results: Findings of research showed that there was a significant different (p < 0.05) between the scores of pre- and post- intervention in most of the sub- scales of quality of life including physical functionning, role limitations due to physical health, role limitations due to emotional problems ؛emotional well-being ؛social functioning ؛and genral health. Conclusion: Reminiscence may, in certain circumstances, be an effective care option for people living in long-stay settings with potential to impact positively on the quality of life of residents.
High glucose condition limited the angiogenic/cardiogenic capacity of murine cardiac progenitor cells in in vitro and in vivo milieu
(2018) Khaksar, M; Sayyari, M; Rezaie, J; Pouyafar, A; Montazersaheb, S; Rahbarghazi, R
Murine c-kit+ cardiac cells were isolated and enriched by magnetic activated cell sorting technique. c-kit+ cells viability and colony-forming activity were evaluated by MTT and clonogenic assay. c-kit+ cells were exposed to endothelial, pericyte, and cardiomyocyte induction media containing 30mM glucose for 7 days. We monitored the level of endothelial (VE-cadherin, CD31, and vWF), pericyte (NG2, ?-SMA, and PDGFR-?), and cardiomyocyte markers (cTnT) using flow cytometry, real-time Polymerase Chain Reaction (PCR), and Enzyme-Linked Immunosorbent Assay (ELISA) analyses. Ultrastructural changes were studied by transmission electron microscopy (TEM) in cells treated with 5-Azacytidine and 30mM glucose. Matrigel plug assay was performed to determine the angio/cardiogenic property of c-kit+ cells in a diabetic mouse model. Glucose of 30mM decreased c-kit+ cells viability and clonogenicity (P < 0.05). The transdifferentiation capacity of c-kit+ cells into the endothelial lineage, pericytes, and cardiomyocytes were reduced through the inhibition of related genes (P < 0.05). TEM analysis revealed cardiomyocyte differentiation rate in c-kit+ cells coincided with an increased intracellular lipid accumulation and reduced number of mitochondria. Similar to in vitro condition, the angiogenic capacity of c-kit+ cells was aborted in vivo indicated by reduced NG2, ?-SMA, CD31, and vWF levels. High glucose condition reduces the angio/cardiogenic capacity of cardiac c-kit+ cells in vitro and in vivo. Significance of the study: High glucose condition seen in diabetes mellitus could affect the regenerative potential of cardiac tissue. The current experiment showed that the exposure of murine cardiac progenitor cells (CD117+ cells) to condition containing 30mM glucose could decrease the differentiation properties into endothelial cells, pericytes, and mature cardiomyocytes in vitro and in vivo. Our finding confirmed that the angiogenic/cardiogenic potential cardiac progenitor cells decrease under treatment with high glucose content as seen in the diabetic condition. é 2018 John Wiley & Sons, Ltd.
A Novel Stimuli-Responsive Magnetite Nanocomposite as De Novo Drug Delivery System
(2018) Mozafari, Z; Massoumi, B; Jaymand, M
A novel stimuli-responsive magnetite nanocomposite as de novo drug delivery system for cancer chemotherapy is developed successfully through the incorporation of magnetite nanoparticles into PEG-b-(PNIPAAm-b-PAA)2 copolymer. The chemical structures of samples were characterized using FTIR and 1H NMR spectroscopies. Furthermore, thermal property, morphology, size, and magnetic properties of the nanocomposite were investigated. The DOX loading and encapsulation efficiencies as well as stimuli-responsive drug release ability of the nanosystem were studied. As results, at pH 5.3 and temperature of 41آ°C the nanocomposite exhibited higher drug release values, which qualified it for cancer chemotherapy according to especial features of cancerous tissue. é 2018 Taylor & Francis
Estimation of economic impacts due to hydatidosis among livestokآ in Kermanshah Province, western Iran
(2018) Vafaei, MR; Faridnia, R; Mostafaei, S; Azadi, Y; Damod, V; Fakhar, M; Kalani, H
Information about inspection of slaughtered animals is a basic approach to review the epidemiological pattern of infectious diseases. Therefore, this study was aimed to determine the prevalence of hydatidosis as well as estimate of relevant economic losses in livestock slaughtered in Kermanshah Province, western Iran, throughout the years 2010-2015. A total of 539,861 livestock examined; 12,413 (2.29%) were infected with hydatidosis. Overall, 4713 (3.21%) of cattle, 6720 (1.97%) of sheep, and 980 (1.86%) of goats were found to be infected with hydatidosis. The total economic loss was USD 457,582. The direct economic loss in cattle was USD 134,164, in sheep USD 53,908, and in goats USD 7407. Furthermore, the indirect economic loss in cattle, sheep, and goats was USD 220,211, USD 41,197, and USD 695, respectively. Targeted investigations on the prevalence of this disease, especially in endemic areas, as well as continuous and regular actions such as the training of those who deal with livestock, the sanitary condemnation of infected organs, the reduction of stray dog population, and the grazing of livestock on safe pasture can provide a clear horizon for an appropriate solution to minimize the infected cases and prevent huge economic losses due to hydatidosis. é 2017, Springer-Verlag London Ltd., part of Springer Nature.
Association of S100B Serum Levels with Metabolic Syndrome and its Components
(2018) Kheirouri, S; Ebrahimi, E; Alizadeh, M
Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome. Materials and Methods: In this study, 44 patients with metabolic syndrome and 44 healthy subjects participated. The participants' body mass index, waist circumference, systolic and diastolic blood pressure were measured. Serum levels of low and high density lipoprotein cholesterol, total cholesterol, triglyceride, fasting blood glucose, insulin, S100B protein were determined by enzymatic and ELISA methods. Results: The participants with metabolic syndrome had significantly higher levels of S100B than those in the control group (p < 0.0001). Serum levels of S100B protein were positively correlated with abdominal obesity (rho = 0.26; p = 0.01) and serum levels of triglyceride (rho = 0.26; p = 0.01). Moreover, serum levels of S100B were higher in subjects with abdominal obesity (p = 0.02), with higher serum triglyceride levels (p = 0.03) and with hypertension (p = 0.01). Conclusion: The findings indicate that there may be a link between S100B protein with abdominal obesity and serum levels of triglycerides. This warrants further research to elucidate whether increased S100B levels in patients with metabolic syndrome are involved in the pathogenesis of cardiovascular disorders.
Data on modeling of enzymatic elimination of Direct Red 81 using Response Surface Methodology
(2018) Kamani, H; Safari, GH; Asgari, G; Ashrafi, SD
In this article, three variables including laccase dose, 2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) dose and pH were used to modeling of Direct Red 81 (DR81) elimination from aqueous solutions by laccase-mediated system. Obtained data indicated that the predicted and experimental values were close for DR81 elimination, and the regression was also able to give a good prediction of response for DR81 elimination (R-Squared = 0.9983). From the experimental, the highest elimination of the DR81 was 95. 5% after 30 min incubation at pH 5, temperature 40 آ°C, ABTS 0.2 mM, and initial concentration of DR81 50 mg L?1 in the presence of 0.2 U mL?1 of the laccase. The data showed that the laccase can be used as a "green"‌ technology for treating of dyes from aqueous solutions. Data analysis was performed using Design-Expert version 7.0.0 (Stat-Ease, trial version). é 2018 The Authors
Electrochemical biosensing using N-GQDs: Recent advances in analytical approach
(2018) Karimzadeh, A; Hasanzadeh, M; Shadjou, N; de la Guardia, M
This review is meant to provide an overview of the electrochemical biosensors based on Nitrogen doped graphene quantum dots (N-GQDs) for analytical approaches, along with significant advances over the last several years in related technologies. In addition, this review described: i) Most frequently applied principles in biosensing based on of N-GQDs ii) The aspects of fabrication in the perspective of biosensing applications iii) The potential of various electrochemical, biosensors for the determination of target analytes within sub-micromolar range and the circumvention of the most serious problem in biosensing will be discussed. iv) Some of multiplex electrochemical biosensors have been discussed with and without labels. v) We also summarize the latest developments in the applications of biosensors methods for detection of important analytes in real samples. vi) The development trends of biosensors are also introduced, including newly developed integrated biosensors based on (N-GQDs). (c) 2018 Elsevier B.V. All rights reserved.