Evaluation of therapeutic effect of nimodipine on facial nerve injury following cerebellopeduncular angle tumor surgery
Kazemzadeh Yaghouti Nobar, Mohammad
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The aim of the present study was to evaluate the effect of nimodipine on the malignant facial nerve malformation of the cerebellopeduncular angle tumor surgery. Materials and Methods: In this clinical trial study, patients with CPA tumors, those with pathologic vestibular schwannoma or meningioma with the largest diameter of 3 cm, who underwent bilateral facial surgery were excluded. The subjects underwent nimodipine 60mg daily every 6 hours after the first day of surgery. Follow up was first 3 and then 6 months after surgery. Weakness and pattern of recovery of facial nerve recovery as well as non-corneal improvement of facial and eyelid and eye condition of patients were evaluated and recorded based on House-Braekmann score. Results: In the evaluation of the results at the 3-month follow-up, there was a significant improvement; in the intervention group 17 patients (56.67%) were recovered from Grades II to IV to Grade I and II and 3 (10%) patients without improvement. They were also in Grades V and VI only one improvement from Grade VI to V was observed (p = 0.001). In the evaluation of the results at the 6-month follow-up, in the intervention group, 18 patients (60%) had improved from Grades II to IV to Grades I and II, and 3 patients (6.5%) had no improvement. They were. Also in Grades V and VI only one improvement from Grade VI to V was observed (p = 0.001). At both follow-up (3 and 6 months later); in the control group, only two cases of Grade II to IV had partial improvement and no improvement in Grades V and VI.