Tumor necrosis factor-alpha gene promoter polymorphism in Iranian patients with chronic hepatitis B
Noori N, B
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Background: Clearance of hepatitis B virus (HBV) infection requires a good host immune response. Cytokines like tumor necrosis factor-alpha (TNF-?) may play a role in such immune response. Genetic changes in TNF-? gene promoter region are known to influence TNF-? expression. We therefore studied the role of one such mutation in chronic HBV infection. Methods: Presence of -308 G/A polymorphism in the promoter region of TNF-? gene was looked for in 100 patients with chronic HBV infection, 91 subjects with spontaneously recovered HBV infection, and 89 healthy controls, using a PCR-RFLP method. Results: Variant alleles (A/A or A/G) were found in 22 of 100 (22%) patients with chronic HBV infection, 21 of 91 (23%) subjects with spontaneous HBV clearance, and 14 of 89 (15.7%) control subjects (p=ns for inter-group comparisons). Conclusion: TNF-? promoter polymorphism -308A is common in Iranian population, but has no association with development of chronic HBV infection. Copyright ط¢آ© 2006 by Indian Society of Gastroenterology.
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