TNF-α gene polymorphisms in Iranian Azeri Turkish patients with Behcet’s Disease
MetadataShow full item record
Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play an important role in the development of the disease. The serum level of tumor necrosis factor (TNF) is elevated in patients with BD, and a dramatic response to anti-TNF-alpha antibody treatment further supports the role of TNF in BD. We investigated the distribution of TNF-alpha promoter -1031T/C and -308G/A polymorphisms in 53 BD patients of Iranian Azeri Turks and 79 matched healthy controls, via the PCR-RFLP technique. The frequency of the TNF-alpha -1031C allele was significantly higher in Behcet's patients than in healthy controls (p < 0.0001, OR = 3.08; 95% CI = 1.73-5.47), whereas the frequency of the TNF-alpha -308A allele was similar in the two compared groups. The frequency of CG haplotype was significantly higher (p < 0.0001, OR = 3.42; 95% CI = 1.89-6.18), and that of the TA haplotype was significantly lower in BD patients than in healthy controls. These results suggest that TNF-alpha is a susceptibility gene for BD in patients from Iranian Azeri Turk ethnic group.
Showing items related by title, author, creator and subject.
Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Sch?nlein purpura susceptibility in Iranian Azeri-Turkish patients Bonyadi, M; Mohammadian, T; Rafeey, M; Sadeghi Shabestri, M; Mortazavi, F; Aliyari, B (2015)Background: Henoch-Sch?nlein purpura (HSP) is the most common small-vessel vasculitis and mainly affects children. Although its pathophysiology is unknown, several studies have indicated the possible involvement of infections ...
Association of ACE, VEGF and CCL2 gene polymorphisms with Henoch-Sch?nlein purpura and an evaluation of the possible interaction effects of these loci in HSP patients Mohammadian, T; Bonyadi, M; Nabat, E; Rafeey, M (2017)Background. Henoch-Sch?nlein purpura (HSP) is a multisystem, small vessel, leucocytoclastic vasculitis. It is predominantly a childhood vasculitis, rarely reported in adults. Studies have shown that several different genetic ...
Evaluating ?238 G>A Polymorphism Association in TNF-? Gene with Metabolic Parameters and Nutritional Intakes Among the Iranian NAFLD Patients Mohseni, F; Rashvand, Z; Najafipour, R; Hadizadeh, S; Moghbelinejad, S (2016)Different studies have shown that ?238 G>A polymorphism in promoter region of tumor necrosis factor alpha (TNF-?) gene is associated with increased risk of non-alcoholic fatty liver disease (NAFLD). The current study ...