The safety and efficacy of biphasic insulin aspart 30 (BIAsp 30) in Iranians with type 2 diabetes: An open-label, non-randomised, multi-centre observational study - The Iran subgroup of the IMPROVE™ study
View/ Open
Date
2010Author
Esteghamati, A
Rajabian, R
Amini, M
Bahrami, A
Khamseh, ME
Afkhami-Ardekani, M
Rizi, EP
Metadata
Show full item recordAbstract
Introduction: To evaluate the clinical profile of BIAsp 30 (30% soluble insulin aspart, 70% protamine-crystallized insulin aspart) (NovoMix30) in type 2 diabetes patients in routine clinical practice in Iran. Material and methods: IMPROVE™ was a 26-week, multinational, open-label, non-randomized study in patients with type 2 diabetes. The safety and efficacy of BIAsp 30 were assessed at baseline and at 13 and 26 weeks. The titration of BIAsp30 was at the physician's discretion. Results: In Iran, 478 patients (47% male) previously treated with oral antidiabetic drugs (OADs) (N = 159, 33.3%) and/or insulin other than BIAsp30 (N = 317, 66.3%) or a few who were treatment-naive (N = 2, 0.4%) participated in the study. After 26 weeks of treatment with BIAsp 30, the rate of reported major hypoglycaemic episodes was reduced by 88.1% from baseline (baseline v. Week 26: 0.303 v. 0.037 episodes/pt-year; p < 0.001). No significant differences in minor hypoglycaemic episodes between baseline and Week 26 were found. Glycaemic control was significantly improved from baseline to Week 26 with a mean HbA1c reduction of 1.2 ± 1.9%. Patients' quality of life as measured by the DiabMedSat questionnaire significantly improved from baseline (58.1) to the end of the study (75.4, p < 0.001). Conclusions: BIAsp 30 therapy appeared safe and effective and improved quality of life in Iranian patients with type 2 diabetes after 26 weeks of treatment.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Insulin resistance and ? cell function in patients with ?-thalassemia major
Ghergherehchi, R; Habibzadeh, A (2015)Iron overload is a common finding in chronically transfused ?-thalassemia major (?-TM) patients with possible effect on ? cell function and insulin resistance. In this study we aimed to evaluate glucose metabolism, insulin ... -
Long-term effects of processed berberis vulgaris on some metabolic syndrome components
Ebrahimi-Mamaghani, M; Arefhosseini, SR; Golzarand, M; Aliasgarzadeh, A; Vahed-Jabbary, M (2009)Introduction: Metabolic syndrome is complex of metabolic disorders that correlates with cardiovascular disease. This study aimed at investigating the effect of processed Berberis vulgaris (B.vulgaris) on some metabolic ... -
Relationship of serum resistin level with insulin resistance indices in non-diabetic and diabetic obese subjects
Mohammadzadeh, G; Zarghami, N; Larijani, B (2007)Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this ...