The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia [O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada]
MetadataShow full item record
CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS: A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks. RESULTS: Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen. CONCLUSION: It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo- AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients. é 2016, Associacao Paulista de Medicina. All rights reserved.
Showing items related by title, author, creator and subject.
Effect of supplementation with grape seed extract (Vitis vinifera) on serum lipid profiles in patient with type 2 diabetes Abedini, S; Pourghassem Gargari, B; Babaei, H; Aliasgarzadeh, A; Pourabdollahi, P (2013)Introduction: Lipid abnormalities are a major cause of cardiovascular diseases in patients with type 2 diabetes. The present study was therefore designed to investigate the supplemental effects of grape seed extract on ...
Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin- Induced Cardiac Toxicity in Wistar Rats Razmaraii, N; Babaei, H; Nayebi, AM; Assadnassab, G; Helan, JA; Azarmi, Y (2016)Purpose: The aim of the present study was to determine the ability of grape seed extract (GSE) as a powerful antioxidant in preventing adverse effect of doxorubicin (DOX) on heart function. Methods: Male rats were divided ...
Effect of supplementation with grape seed (Vitis vinifera) extract on antioxidant status and lipid peroxidation in patient with type II diabetes Pourghassem-Gargari, B; Abedini, S; Babaei, H; Aliasgarzadeh, A; Pourabdollahi, P (2011)To determine the effects of grape seed extract (GSE) supplementation on antioxidant defense system and lipid peroxidation in persons with type 2 diabetes mellitus (T2D). During a randomized double blind clinical trial adult ...